眼表鳞状上皮肿瘤切除术后羊膜移植联合局部应用干扰素α-2b
Amniotic membrane transplantation with topical interferon alfa-2b after excision of ocular surface squamous neoplasia.
作者信息
Xie Hua-Tao, Zhang Ying-Ying, Jiang Dong-Ling, Wu Jun, Wang Jia-Song, Zhang Ming-Chang
机构信息
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
出版信息
Int J Ophthalmol. 2018 Jan 18;11(1):160-162. doi: 10.18240/ijo.2018.01.24. eCollection 2018.
Abstract
To evaluate the outcome of amniotic membrane transplantation (AMT) after tumor excision followed by topical interferon alfa-2b (IFNα2b) drops for primary ocular surface squamous neoplasia (OSSN). Twelve eyes of 12 patients with a mean age of 66±10y were included. The average follow-up was 23±10mo. All 12 patients had limbal involvement. Smooth ocular surface and transparent cornea were achieved in all cases. No sign of inflammation, neovascularization, symblepharon or recurrence was noted at the last follow-up. We conclude that AMT with topical IFNα2b drops restores a healthy ocular surface in OSSN without recurrence.
摘要
评估原发性眼表鳞状上皮肿瘤（OSSN）切除肿瘤后羊膜移植（AMT）联合局部应用干扰素α-2b（IFNα2b）滴眼液的治疗效果。纳入12例患者的12只眼，平均年龄66±10岁。平均随访时间为23±10个月。所有12例患者均有角膜缘受累。所有病例均实现了眼表光滑和角膜透明。末次随访时未发现炎症、新生血管、睑球粘连或复发迹象。我们得出结论，AMT联合局部应用IFNα2b滴眼液可使OSSN患者恢复健康眼表且无复发。
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