Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
Mod Pathol. 2012 Jan;25 Suppl 1:S39-42. doi: 10.1038/modpathol.2011.149.
The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by in situ hybridization.
目前对诊断淋巴样肉芽肿病（LYG）的组织学标准进行了回顾和总结。大多数患者表现为累及肺部的多个双侧结节。诊断所必需的主要组织学特征包括混合性单核细胞浸润，表现为血管浸润，大量 T 细胞和数量不等的 CD20 阳性 B 细胞，原位杂交显示 EBER 阳性。
