a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , China.
b Graduate School, Peking Union Medical College , Beijing , China.
Int J Food Sci Nutr. 2018 Dec;69(8):976-984. doi: 10.1080/09637486.2018.1428538. Epub 2018 Jan 28.
The effect of different individual TFA isomers on cardiovascular disease (CVD) has been a limited study, especially for stroke. We aimed to investigate the relationships between four major plasma TFA isomer (elaidic, vaccenic, palmitelaidic and linolelaidic acid) concentrations and the risk of CVD, stroke and non-stroke CVD. A cross-sectional study was conducted, utilising a nationally representative sample of US adults in the National Health and Nutrition Examination Survey. Among the 3504 participants, 304 participants self-reported CVD history. The highest quintile of elaidic acid intake was associated with a 233% higher CVD risk (p = .010). Adjusted for age, gender and race, palmitelaidic acid was associated with a decreased CVD risk, but the effect size was diminished in a subsequent analysis model. For stroke risk, we failed to identify any associations. In addition to elaidic acid, the health effect of palmitelaidic acid should be paid more attention in the future studies.
不同个体反式脂肪酸异构体对心血管疾病（CVD）的影响研究有限，尤其是对中风的影响。我们旨在研究四种主要的血浆反式脂肪酸异构体（油酸、蓖麻油酸、棕榈油酸和亚油酸）浓度与 CVD、中风和非中风性 CVD 风险之间的关系。采用美国全国健康和营养调查的全国代表性成年人样本进行了一项横断面研究。在 3504 名参与者中，有 304 名参与者自述患有 CVD。摄入最高五分位的油酸与 CVD 风险增加 233%相关（p=0.010）。在调整年龄、性别和种族后，棕榈油酸与 CVD 风险降低相关，但在后续分析模型中，其效应大小降低。对于中风风险，我们未发现任何关联。除了油酸外，未来的研究还应更加关注棕榈油酸的健康影响。
