神经节苷脂 GM3 及其在癌症中的作用。
Ganglioside GM3 and Its Role in Cancer.
机构信息
Sorbonne Universite, CNRS, Institut Parisien de Chimie Moleculaire (UMR 8232), 4 Place Jussieu, 75005 Paris, France.
Drug Sciences Department, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy.
出版信息
Curr Med Chem. 2019;26(16):2933-2947. doi: 10.2174/0929867325666180129100619.
Ganglioside GM3 is strongly related with human tumors, such as lung, brain cancers and melanomas, and more and more evidences have revealed that GM3 possesses powerful effects on cancer development and progression. GM3 is over expressed on several types of cancers, and can be as a tumor-associated carbohydrate antigen, used for immunotherapy of cancers. GM3 can also inhibit tumor cells growth by anti-angiogenesis or motility and so on. Especially, GM3 has effects on the EGFR tyrosine kinase signaling, uPAR-related signaling and glycolipid-enriched microdomains, which are essential for cancer signaling conduction. It is obvious that GM3 will be a promising target for cancer treatment.
神经节苷脂 GM3 与人的肿瘤密切相关，如肺癌、脑癌和黑色素瘤等，越来越多的证据表明 GM3 对癌症的发生和发展具有强大的影响。GM3 在几种类型的癌症中过表达，并且可以作为肿瘤相关的碳水化合物抗原，用于癌症的免疫治疗。GM3 还可以通过抗血管生成或运动等方式抑制肿瘤细胞的生长。特别是，GM3 对表皮生长因子受体酪氨酸激酶信号、uPAR 相关信号和富含糖脂的微区具有作用，这些对癌症信号传导至关重要。显然，GM3 将成为癌症治疗的一个有前途的靶点。
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