Fåhraeus L, Sydsjö A, Wallentin L
Fertil Steril. 1986 Apr;45(4):503-6.
Ten women with endometriosis were treated with medroxyprogesterone acetate (MPA), 150 mg intramuscularly every second week. After 2 weeks, there was a significant (8%) decrease in the high-density lipoprotein (HDL) concentration. This reduction became more pronounced after 8 and 24 weeks' medication. The HDL reduction was confined to the HDL2 subfraction, which was decreased by 15%, 33%, and 58% after 2, 8, and 24 weeks, respectively; there was no significant change in the HDL3 concentration. During treatment, there was a continuous increase in the mean MPA plasma level and a strong inverse correlation between this level and the mean HDL and HDL2 cholesterol concentrations. It was concluded that MPA affects HDL metabolism in a dose-dependent way and in the same direction as other progestins.
十名患有子宫内膜异位症的女性接受了醋酸甲羟孕酮（MPA）治疗，每隔一周肌肉注射150毫克。两周后，高密度脂蛋白（HDL）浓度显著下降（8%）。在用药8周和24周后，这种下降变得更加明显。HDL的下降仅限于HDL2亚组分，在2周、8周和24周后分别下降了15%、33%和58%；HDL3浓度没有显著变化。在治疗期间，MPA血浆平均水平持续升高，且该水平与HDL及HDL2胆固醇平均浓度之间存在强烈的负相关。得出的结论是，MPA以剂量依赖的方式影响HDL代谢，且与其他孕激素的作用方向相同。
