恶性肿瘤相关性血脂异常
Malignancy-associated dyslipidemia.
作者信息
Bielecka-Dąbrowa Agata, Hannam Simon, Rysz Jacek, Banach Maciej
机构信息
Department of Hypertension, Medical University of Lodz, Poland.
出版信息
Open Cardiovasc Med J. 2011;5:35-40. doi: 10.2174/1874192401105010035. Epub 2011 Feb 24.
Abstract
Cholesterol and triglycerides, important lipid constituents of cell, are essential to carry out several vital physiological functions. Lipids might be associated with cancers because they play a key role in the maintenance of cell integrity. The pathway for cholesterol synthesis may also produce various tumorigenic compounds and cholesterol serves as a precursor for the synthesis of many sex hormones linked to increased risk of various cancers. In some malignant diseases, blood cholesterol undergoes early and significant changes. The mechanism for the link between cancer and cholesterol remains controversial. The dates from studies are confusing because both hypolipidemia and hypercholesterolemia might be connected with malignancy. Not only cancers but also antineoplastic therapies have an influence on lipid profile. There are also dates suggesting that antihyperlipemic drugs might nfluenced malignancy.
摘要
胆固醇和甘油三酯是细胞重要的脂质成分，对执行多种重要生理功能至关重要。脂质可能与癌症有关，因为它们在维持细胞完整性方面发挥关键作用。胆固醇合成途径也可能产生各种致癌化合物，并且胆固醇是许多与多种癌症风险增加相关的性激素合成的前体。在一些恶性疾病中，血液胆固醇会发生早期且显著的变化。癌症与胆固醇之间联系的机制仍存在争议。研究数据令人困惑，因为低脂血症和高胆固醇血症都可能与恶性肿瘤有关。不仅癌症，而且抗肿瘤治疗也会对血脂谱产生影响。也有数据表明降血脂药物可能会影响恶性肿瘤。
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