Prickartz Alexander, Lüsebrink Jessica, Khalfaoui Soumaya, Schildgen Oliver, Schildgen Verena, Windisch Wolfram, Brockmann Michael
Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, Universität Witten-Herdecke, Alfred-Herrhausen-Straße 50, Witten 58448, Germany.
Institut für Pathologie, Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten/Herdecke mit Sitz in Köln, Ostmerheimer Str. 200, Köln/Cologne D-51109, Germany.
J Fungi (Basel). 2016 May 28;2(2):16. doi: 10.3390/jof2020016.
Non-pneumonia colonization is thought to occur frequently in immunocompetent individuals. The aim was to analyze if low-titer detections have more impact than just colonization. From our total cohort of patients for which testing by qPCR was requested, we selected exclusively those that were fully immunocompetent. Patients were defined as fully immunocompetent if they did not receive immunosuppressive therapy, displayed regular antibody titers, and did not suffer from acquired, inherited or autoimmune diseases. Only those patients with complete medical records available were included. A retrospective analysis identified patients with colonization and successful antibiotic therapy in response to laboratory pathogen detection. We identified 30 fully immunocompetent patients with colonization suspected to suffer from infection with the pathogen, but with milder symptoms than pneumonia. All patients were successfully treated with cotrimoxazole against and resolved from chronic cough and recurrent pulmonary infections. The fact that all patients displayed recovery from their clinical symptoms gives raise to the hypothesis that infections may also occur in immunocompetent patients but with milder symptoms.
非肺炎定植被认为在免疫功能正常的个体中频繁发生。目的是分析低滴度检测是否比单纯定植有更大影响。在我们全部因qPCR检测而就诊的患者队列中，我们仅选择那些完全免疫功能正常的患者。如果患者未接受免疫抑制治疗、抗体滴度正常且未患有获得性、遗传性或自身免疫性疾病，则被定义为完全免疫功能正常。仅纳入那些有完整病历的患者。一项回顾性分析确定了因实验室病原体检测而发生定植并接受成功抗生素治疗的患者。我们确定了30名完全免疫功能正常的患者，他们疑似病原体感染但症状比肺炎轻。所有患者均接受复方新诺明成功治疗，慢性咳嗽和反复肺部感染症状得到缓解。所有患者临床症状均恢复这一事实引发了这样的假设，即免疫功能正常的患者也可能发生感染，但症状较轻。
