Shurygina L V, Kravtsov A A, Zlishcheva E I, Nemchinova E A, Bukin D Yu
A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia,
Bull Exp Biol Med. 2014 Nov;158(1):49-52. doi: 10.1007/s10517-014-2689-4. Epub 2014 Nov 19.
The study demonstrated neuroprotective action of novel chemical agent, potassium salt of comenic acid, against the glutamate-induced cytotoxicity on the model of cultured cerebral neurons. Potassium comenate (0.001-1.0 mM) significantly decreased the rate of glutamateinduced neuronal death. The highest viability of the cultured neurons during postglutamate time was observed when potassium comenate was applied in a concentration of 0.1 mM.
该研究证明了新型化学试剂 comenic 酸的钾盐对培养的脑神经元模型上谷氨酸诱导的细胞毒性具有神经保护作用。Comenic 酸钾（0.001 - 1.0 mM）显著降低了谷氨酸诱导的神经元死亡率。当以 0.1 mM 的浓度应用 Comenic 酸钾时，观察到谷氨酸作用后培养神经元的存活率最高。
