Kuban State University, Krasnodar, Russia.
Federal Research Center South Research Center, Russian Academy of Sciences, Rostovon-Don, Russia.
Bull Exp Biol Med. 2021 Sep;171(5):619-622. doi: 10.1007/s10517-021-05281-6. Epub 2021 Oct 7.
We studied the antioxidant and cytoprotective effects of meconic acid in the model systems. Meconic acid, similar to commercial drug Mexidol, reduced the intensity of chemiluminescence in the model system of yolk lipoproteins. Meconic acid also reduced the toxic effect of glutamate on neurons in the primary cerebellar culture, but had no effect on cell viability under normal conditions.
我们研究了次没食子酸在模型系统中的抗氧化和细胞保护作用。次没食子酸与商业药物美克西多相似，降低了蛋黄脂蛋白模型系统中的化学发光强度。次没食子酸还降低了谷氨酸对原代小脑培养神经元的毒性作用，但在正常条件下对细胞活力没有影响。
