乙型肝炎e抗原和抗体在智障乙肝表面抗原携带者中的流行病学研究

Epidemiology of hepatitis B e antigen and antibody in mentally retarded HBsAg carriers.

作者信息

Lohiya G, Lohiya S, Ngo V T, Crinella R

出版信息

Hepatology. 1986 Mar-Apr;6(2):163-6. doi: 10.1002/hep.1840060202.

Abstract

Screening for HBeAg and anti-HBe was performed on 133 carriers of HBsAg in an institution for the mentally retarded. By radioimmunoassay, the prevalences of HBeAg and anti-HBe were determined to be 16 and 78%, respectively. HBeAg prevalence was significantly different in the following pairs of carriers: 70% in blacks, 10% in whites, and 35% in carriers with Down's syndrome, 8% in carriers without Down's syndrome. Mean age of HBeAg-positive carriers (25.7 years) was lower than HBeAg-negative carriers (29.6 years, p less than 0.05). SGPT levels were abnormal in 66% of HBeAg-positive and 25% of HBeAg-negative carriers (p less than 0.01). This suggests an association between HBeAg positivity and functional liver impairment.

摘要

在一所智障机构中，对133名乙肝表面抗原（HBsAg）携带者进行了e抗原（HBeAg）和e抗体（抗 - HBe）筛查。通过放射免疫测定法，确定HBeAg和抗 - HBe的流行率分别为16%和78%。在以下几组携带者中，HBeAg流行率存在显著差异：黑人携带者中为70%，白人携带者中为10%；唐氏综合征携带者中为35%，非唐氏综合征携带者中为8%。HBeAg阳性携带者的平均年龄（25.7岁）低于HBeAg阴性携带者（29.6岁，p < 0.05）。66%的HBeAg阳性携带者和25%的HBeAg阴性携带者谷丙转氨酶（SGPT）水平异常（p < 0.01）。这表明HBeAg阳性与功能性肝损伤之间存在关联。