不同乙肝表面抗原携带者群体中乙肝“e”抗原及其抗体的流行率。

Prevalence of hepatitis B "e" antigen and its antibody in various HBsAg carrier populations.

作者信息

Szmuness W, Neurath A R, Stevens C E, Strick N, Harley E J

出版信息

Am J Epidemiol. 1981 Feb;113(2):113-21. doi: 10.1093/oxfordjournals.aje.a113074.

DOI:10.1093/oxfordjournals.aje.a113074

Abstract

A total of 749 persistent carriers of hepatitis B surface antigen (HBsAg) were tested for hepatitis B e antigen/antibody to e antigen (HBeAg/anti-HBe) by a radioimmunoassay method. The prevalence of HBeAg was found to be: 9.1% in carrier-blood donors, 10.3% in mentally retarded patients without Down's syndrome, 23.6% in Chinese-Americans, 35.3% in drug addicts, 39.2% in mentally retarded patients with Down's syndrome, 61.4% in homosexual men, and 71.2% in dialysis patients. The prevalence of HBeAg appears to be independent of sex, race, and HBsAg antigenic subtype. Younger carries tend to be more frequently HBeAg positive than older ones. All individuals acutely infected with hepatitis B virus become at least transiently positive for HBeAg. Appearance or clearance of HBsAg, HBeAg and their corresponding antibodies seem to be interrelated.

摘要

采用放射免疫分析法对749名乙型肝炎表面抗原（HBsAg）持续携带者进行了乙型肝炎e抗原/e抗原抗体（HBeAg/抗-HBe）检测。结果发现，HBeAg的流行率如下：献血携带者中为9.1%，非唐氏综合征的智障患者中为10.3%，华裔美国人中为23.6%，吸毒者中为35.3%，唐氏综合征的智障患者中为39.2%，男同性恋者中为61.4%，透析患者中为71.2%。HBeAg的流行率似乎与性别、种族和HBsAg抗原亚型无关。年轻携带者比年长携带者HBeAg阳性的频率更高。所有急性感染乙型肝炎病毒的个体HBeAg至少会出现短暂阳性。HBsAg、HBeAg及其相应抗体的出现或清除似乎相互关联。