Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China.
State key of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, 130022, P. R. China.
Chem Asian J. 2018 Apr 16;13(8):989-995. doi: 10.1002/asia.201701727. Epub 2018 Mar 13.
The development of robust photothermal agents for near-infrared (NIR) imaging is a great challenge. Herein, we report the design and synthesis of a new photothermal agent, based on the aza-boron-dipyrromethene framework (azaBDP). This compound possessed excellent photostability and high photothermal-conversion efficiency (50 %) under NIR laser irradiation. When the photothermal properties of this compound were utilized for tumor inhibition, stable long-term fluorescence was observed in living animals. Photothermal treatment efficiently suppressed tumor growth, as evidenced by in vitro and in vivo experiments. Furthermore, NIR emission could be detected by using an imaging system and therapeutic self-monitoring was achieved by using NIR imaging.
开发用于近红外（NIR）成像的稳健光热剂是一项巨大的挑战。在此，我们报告了一种基于氮杂-硼-二吡咯甲川（azaBDP）框架的新型光热剂的设计和合成。该化合物在近红外激光照射下具有出色的光稳定性和高光热转换效率（50%）。当该化合物的光热特性用于抑制肿瘤时，在活体动物中观察到稳定的长期荧光。光热治疗有效地抑制了肿瘤的生长，这一点在体外和体内实验中都得到了证明。此外，NIR 发射可以通过成像系统进行检测，并且可以通过 NIR 成像实现治疗的自我监测。
