Hara J, Kawa-Ha K, Yumura K, Ishihara S, Doi S, Yabuuchi H
Jpn J Cancer Res. 1986 Jan;77(1):28-31.
In an attempt to look further at the problem of heterogeneity, we have studied the immunoglobulin (Ig) gene organization in leukemic cells from 20 children with acute lymphoblastic leukemia (common ALL). Nineteen cases were divided into two subgroups: 12 cases with rearrangement of the Ig heavy (H) chain genes and 7 cases with rearrangement of both the Ig H and light (L) chain genes. No Ig gene rearrangement was found in one case. These findings indicate that there is more heterogeneity among patients with common ALL than has previously been believed.
为了进一步研究异质性问题，我们研究了20例急性淋巴细胞白血病（普通型ALL）患儿白血病细胞中的免疫球蛋白（Ig）基因组织。19例分为两个亚组：12例Ig重链（H）基因重排，7例Ig H链和轻链（L）基因均重排。1例未发现Ig基因重排。这些发现表明，普通型ALL患者之间的异质性比以前认为的更多。
