Corbett Duane B, Fennell Curtis, Peroutky Kylene, Kingsley J Derek, Glickman Ellen L
Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, FL, 32611, USA.
Department of Kinesiology, College of Education, University of Montevallo, Montevallo, AL, 35115, USA.
BMC Res Notes. 2018 Jan 29;11(1):80. doi: 10.1186/s13104-018-3151-x.
To determine the effectiveness of a low-cost 12-week worksite physical activity intervention targeting a goal of 10,000 steps per day on reducing anthropometric indices, blood pressure indices, and plasma biomarkers of cardiovascular disease (CVD) risk among the employees of a major university.
Fifty university employees (n = 43 female, n = 7 male; mean age = 48 ± 10 years) participated in the 12-week physical activity intervention (60 min, 3 day/week). Each session included both aerobic (cardiorespiratory endurance) and muscle-strengthening (resistance) physical activity using existing university facilities and equipment. Anthropometric indices, blood pressure indices, and plasma biomarkers of CVD risk assessed included those for obesity (body mass index), hypertension (systolic blood pressure, SBP; diastolic blood pressure, DBP), dyslipidemia (high-density lipoprotein, HDL; low-density lipoprotein, LDL; total serum cholesterol), and prediabetes (impaired fasting glucose, IFG). Steps per day were assessed using a wrist-worn activity monitor. Participants were given the goal of 10,000 steps per day and categorized as either compliers (≥ 10,000 steps per day on average) or non-compliers (< 10,000 steps per day on average) based on their ability to achieve this goal.
Overall, 34% of participants at baseline were already at an elevated risk of CVD due to age. On average, 28% of participants adhered to the goal of 10,000 steps per day. After 12-weeks, participants in both groups (compliers and non-compliers) had lower BMI scores (p < 0.001), lower HDL scores (p < 0.034), and higher IFG scores (p < 0.001). The non-compliers had a greater reduction of BMI scores than the compliers (p = 0.003). Participants at risk for CVD had greater reductions than those not at risk for several risk factors, including SBP (p = 0.020), DBP (p = 0.028), IFG (p = 0.002), LDL (p = 0.006), and total serum cholesterol (p = 0.009).
While the physical activity intervention showed mixed results overall with both favorable changes in anthropometric indices yet unfavorable changes in plasma biomarkers, it was particularly beneficial in regards to both blood pressure indices and plasma biomarkers among those already at risk of CVD. Trial registration ClinicalTrials.gov NCT03385447; retrospectively registered.
为确定一项针对每天10000步目标的低成本、为期12周的工作场所身体活动干预措施，对一所主要大学员工的人体测量指标、血压指标以及心血管疾病（CVD）风险的血浆生物标志物的降低效果。
50名大学员工（43名女性，7名男性；平均年龄 = 48 ± 10岁）参加了为期12周的身体活动干预（60分钟，每周3天）。每次课程都包括利用大学现有的设施和设备进行的有氧运动（心肺耐力）和肌肉强化（抗阻）身体活动。评估的人体测量指标、血压指标以及CVD风险的血浆生物标志物包括肥胖（体重指数）、高血压（收缩压，SBP；舒张压，DBP）、血脂异常（高密度脂蛋白，HDL；低密度脂蛋白，LDL；总血清胆固醇）以及糖尿病前期（空腹血糖受损，IFG）相关指标。每天的步数通过佩戴在手腕上的活动监测器进行评估。参与者被设定了每天10000步的目标，并根据他们实现该目标的能力分为达标者（平均每天≥10000步）或未达标者（平均每天<10000步）。
总体而言，34%的基线参与者由于年龄因素已经处于CVD风险升高状态。平均而言，28%的参与者坚持了每天10000步的目标。12周后，两组参与者（达标者和未达标者）的体重指数得分均降低（p < 0.001），高密度脂蛋白得分降低（p < 0.034），空腹血糖受损得分升高（p < 0.001）。未达标者的体重指数得分降幅大于达标者（p = 0.003）。有CVD风险的参与者在包括收缩压（p = 0.020）、舒张压（p = 0.028）、空腹血糖受损（p = 0.002）、低密度脂蛋白（p = 0.006）和总血清胆固醇（p = 0.009）等几个风险因素方面的降幅大于无风险者。
虽然身体活动干预总体结果好坏参半，人体测量指标有有利变化但血浆生物标志物有不利变化，但对于已经有CVD风险的人群，在血压指标和血浆生物标志物方面尤其有益。试验注册ClinicalTrials.gov NCT03385447；回顾性注册。
