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NF-κB、炎症、免疫与癌症：崭露头角。

NF-κB, inflammation, immunity and cancer: coming of age.

机构信息

Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-8582, Japan.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

Nat Rev Immunol. 2018 May;18(5):309-324. doi: 10.1038/nri.2017.142. Epub 2018 Jan 22.

DOI:10.1038/nri.2017.142
PMID:29379212
Abstract

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a molecular lynchpin that links persistent infections and chronic inflammation to increased cancer risk. The young field of inflammation and cancer has now come of age, and inflammation has been recognized by the broad cancer research community as a hallmark and cause of cancer. Here, we discuss how the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity.

摘要

自核因子-κB（NF-κB）首次被证明作为将持续性感染和慢性炎症与癌症风险增加联系起来的分子关键因素以来，已经过去了 14 年。炎症与癌症这一新兴领域如今已经成熟，炎症已被广泛的癌症研究界公认为癌症的一个标志和原因。在这里，我们讨论了 NF-κB 在将炎症与癌症联系起来的作用的最初发现如何导致对肿瘤引发的炎症及其对抗癌免疫的影响的理解的提高。

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本文引用的文献

[1]
Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.

Cancer Cell. 2017-12-11

[2]
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity.

Nature. 2017-11-16

[3]
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.

Science. 2017-11-2

[4]
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients.

Science. 2018-1-5

[5]
An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.

Immunity. 2017-9-19

[6]
NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer.

Cell. 2017-9-7

[7]
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.

Nat Cell Biol. 2017-9

[8]
Cancer secretome and inflammation: The bright and the dark sides of NF-κB.

Semin Cell Dev Biol. 2017-8-2

[9]
DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression.

J Cancer Metastasis Treat. 2017

[10]
The non-canonical NF-κB pathway in immunity and inflammation.

Nat Rev Immunol. 2017-9

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