64层计算机断层扫描灌注成像对肺癌患者辐射剂量的评估：特别提及SSDE——一家三级医院的初步经验
Appraisal of radiation dose with 64-slice computed tomography perfusion in lung cancer patients with special reference to SSDE: An initial experience in a tertiary care hospital.
作者信息
Bhatt Shuchi, Srivastava Ajai K, Meena Neha, Thakur Shweta
机构信息
Department of Radio-diagnosis, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Indian J Radiol Imaging. 2017 Oct-Dec;27(4):389-396. doi: 10.4103/ijri.IJRI_44_17.
CONTEXT
Computed tomography perfusion (CTP) is an important functional tool for lung cancer. It is expected to deliver high radiation dose, making its accurate estimation important. Size-specific dose estimate (SSDE) is a new dose metric, which includes the scanner output as well as the patient size.
AIMS
To determine radiation dose [CT dose index (CTDI), dose length product (DLP), effective dose (ED), and SSDE] for CTP in lung cancer and the correlation of CTDI, DLP, and SSDE with effective diameter and SSDE with weight, body mass index (BMI), and the scan length.
SETTINGS AND DESIGN
Cross-sectional study in the Department of Radio-diagnosis from October 2015 to March 2016.
PATIENTS AND METHODS
Due ethical approval and informed consent was taken. Thirty consecutive adult patients of lung cancer undergoing CTP study were included; various radiation dose parameters were determined and presented as mean ± SD.
STATISTICAL ANALYSIS USED
Paired Student's -test and Pearson correlation using Statistical Package for the Social Sciences, Version 16.
RESULTS
Mean radiation dose was CTDI = 270.138 ± 1.627 mGy, DLP = 681 ± 53.496 mGy.cm, ED = 12.501 ± 0.923 mSv, SSDE = 388.90 ± 81.27 mGy. The CTDI and DLP had significant positive correlation ( = 0.556, = 0.000 and = 0.522, = 0.003, respectively) with effective diameter. SSDE had strong negative correlation ( = -0.997, = 0.000) with effective diameter, significant negative correlation with the BMI ( = -0.889; = 0.000) and weight ( = -0.910, = 0.000) of patients. Scan length was not significantly correlated in SSDE ( = -0.012, = 0.951).
CONCLUSIONS
Smaller sized patients had greater SSDE.
背景
计算机断层扫描灌注成像（CTP）是用于肺癌的一项重要功能检查手段。预计其辐射剂量较高，因此准确估算辐射剂量很重要。特定尺寸剂量估算（SSDE）是一种新的剂量指标，它既包括扫描仪输出剂量，也考虑了患者体型。
目的
确定肺癌CTP检查的辐射剂量[CT剂量指数（CTDI）、剂量长度乘积（DLP）、有效剂量（ED）和SSDE]，以及CTDI、DLP和SSDE与有效直径的相关性，SSDE与体重、体重指数（BMI）及扫描长度的相关性。
设置与设计
2015年10月至2016年3月在放射诊断科进行的横断面研究。
患者与方法
获得伦理批准并取得知情同意。纳入30例连续接受CTP检查的成年肺癌患者；测定各种辐射剂量参数，并以均值±标准差表示。
所用统计分析方法
使用社会科学统计软件包第16版进行配对t检验和Pearson相关性分析。
结果
平均辐射剂量为CTDI = 270.138 ± 1.627 mGy，DLP = 681 ± 53.496 mGy·cm，ED = 12.501 ± 0.923 mSv，SSDE = 388.90 ± 81.27 mGy。CTDI和DLP与有效直径呈显著正相关（分别为r = 0.556，P = 0.000和r = 0.522，P = 0.003）。SSDE与有效直径呈强负相关（r = -0.997，P = 0.000），与患者的BMI（r = -0.889；P = 0.000）和体重（r = -0.910，P = 0.000）呈显著负相关。扫描长度与SSDE无显著相关性（r = -0.012，P = 0.951）。
结论
体型较小的患者SSDE较高。
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