Paul Strickland Scanner Centre, Mount Vernon Hospital, Rickmansworth Road, Northwood, Middlesex HA6 2RN, UK.
Eur Radiol. 2011 May;21(5):974-81. doi: 10.1007/s00330-010-1997-y. Epub 2010 Nov 18.
To evaluate the radiation doses delivered during volumetric helical perfusion CT of the thorax, abdomen or pelvis.
The dose-length product (DLP) and CT dose index (CTDIvol) were recorded and effective dose (E) determined for patients undergoing CT (4D adaptive spiral) for tumour evaluation. Image noise and contrast to noise (CNR) at peak enhancement were also assessed for quality.
Forty two consecutive examinations were included: thorax (16), abdomen (10), pelvis (16). Z-axis coverage ranged from 11.4 to 15.7 cm. Mean DLP was 1288.8 mGy.cm (range: 648 to 2456 mGy.cm). Mean CTDIvol was 96.2 mGy (range: 32.3 to 169.4 mGy). Mean effective dose was 19.6 mSv (range: 12.3 mSv to 36.7 mSv). In comparison mean DLP and effective dose was 885.2 mGy.cm (range: 504 to 1633 mGy.cm) and 13.3 mSV (range: 7.8 to 24.5 mSv) respectively for the standard staging CT thorax, abdomen and pelvis. Mean tumour CNR at peak enhancement was 1.87.
The radiation dose imposed by perfusion CT was on average 1.5 times that of a CT thorax, abdomen and pelvis. The dose is not insubstantial, and must be balanced by the potential clinical utility of additional physiologic data. Further efforts towards dose reduction should be encouraged.
评估胸部、腹部或骨盆容积螺旋灌注 CT 检查的辐射剂量。
对因肿瘤评估行 CT（4D 自适应螺旋）检查的患者记录剂量长度乘积（DLP）和 CT 剂量指数（CTDIvol），并计算有效剂量（E）。还评估了峰值增强时的图像噪声和对比噪声比（CNR），以评估质量。
共纳入 42 例连续检查：胸部（16 例）、腹部（10 例）、骨盆（16 例）。Z 轴覆盖范围为 11.4-15.7cm。平均 DLP 为 1288.8mGy·cm（范围：648-2456mGy·cm）。平均 CTDIvol 为 96.2mGy（范围：32.3-169.4mGy）。平均有效剂量为 19.6mSv（范围：12.3mSv-36.7mSv）。相比之下，标准胸部、腹部和骨盆 CT 分期检查的平均 DLP 和有效剂量分别为 885.2mGy·cm（范围：504-1633mGy·cm）和 13.3mSv（范围：7.8-24.5mSv）。峰值增强时平均肿瘤 CNR 为 1.87。
与胸部、腹部和骨盆 CT 相比，灌注 CT 引起的辐射剂量平均增加了 1.5 倍。剂量不容忽视，必须权衡额外生理数据的潜在临床效用。应鼓励进一步努力降低剂量。
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