Toyomaki Atsuhito, Hashimoto Naoki, Kako Yuki, Tomimatsu Yoshiro, Koyama Tsukasa, Kusumi Ichiro
Department of Psychiatry, Graduate School of Medicine, Hokkaido University, N15, W7, Sapporo, 060-8638, Japan.
Schizophr Res Cogn. 2015 Sep 9;2(3):166-169. doi: 10.1016/j.scog.2015.07.002. eCollection 2015 Sep.
The P50 is an early component of auditory evoked potentials and a measure of sensory gating deficits. This evoked potential component is thought to be an important endophenotype candidate for schizophrenia. Recent research suggests that instead of the P50 ratio, S1 and S2 amplitudes should be evaluated for sensory gating. However, no studies have focused on the relationship between cognitive dysfunction and P50 sensory gating deficits using S1 and S2 amplitudes. The purpose of the present study was to investigate the association between the P50 ratio (S2/S1), S1 and S2 amplitudes, and neuropsychological cognitive domains using stepwise multiple linear regression analyses. Results demonstrated a significant relationship between executive functioning and the P50 ratio and between sustained attention and S2 amplitude, respectively. Our findings suggest that the P50 ratio and S2 amplitude reflect distinct neurophysiological substrates associated with different cognitive functions.
P50是听觉诱发电位的早期成分，也是感觉门控缺陷的一种度量。这种诱发电位成分被认为是精神分裂症的一个重要内表型候选指标。最近的研究表明，对于感觉门控，应评估S1和S2波幅，而非P50比值。然而，尚无研究聚焦于使用S1和S2波幅来探讨认知功能障碍与P50感觉门控缺陷之间的关系。本研究的目的是通过逐步多元线性回归分析，研究P50比值（S2/S1）、S1和S2波幅与神经心理学认知领域之间的关联。结果分别显示执行功能与P50比值之间以及持续注意力与S2波幅之间存在显著关系。我们的研究结果表明，P50比值和S2波幅反映了与不同认知功能相关的不同神经生理基质。
