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腰高比与腹主动脉钙化的相关性:一项横断面研究。

Associations between waist-to-height ratio and abdominal aortic calcification: A cross-sectional study.

机构信息

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.

出版信息

Medicine (Baltimore). 2024 Jun 14;103(24):e38608. doi: 10.1097/MD.0000000000038608.

Abstract

Waist-to-height ratio (WtHR) is a validated biomarker of central obesity that appears to be preferable to other body composition measurements in the evaluation of cardiovascular disease. The goal of this research was to explore the connection between WtHR and abdominal aortic calcification (AAC) among adults. On the basis of data from the 2013 to 2014 National Health and Nutrition Examination Survey, multivariate logistic regression, sensitivity analysis, as well as smoothed curve fitting were used to evaluate the connection between WtHR and AAC. Subgroup analyses along with interaction tests were done to see if this link was consistent across populations. Among 3079 participants aged >40 years, there was a negative association between WtHR and ACC. Each 1-unit emergence of WtHR was related to a 2% reduction in the probability of severe AAC in the entirely adjusted model (odds ratio = 0.02, 95% confidence interval: [0.00-0.12]). Participants in the highest WtHR quartile were 39% less likely to acquire severe AAC compared with those in the lowest quartile. (odds ratio = 0.61, 95% confidence interval: [0.37-1.00]). This negative association was more pronounced in the diabetes subgroup. We discovered a reversed U-shaped association between WtHR as well as AAC score utilizing a 2-stage linear regression model, with an intersection point of 0.56. WtHR was negatively associated with AAC among US adults.

摘要

腰高比(WtHR)是一种经过验证的中心性肥胖生物标志物,在评估心血管疾病方面,它似乎优于其他身体成分测量指标。本研究旨在探讨成年人 WtHR 与腹主动脉钙化(AAC)之间的关系。基于 2013-2014 年全国健康与营养调查的数据,采用多变量逻辑回归、敏感性分析以及平滑曲线拟合来评估 WtHR 与 AAC 之间的关系。进行亚组分析和交互检验,以确定这种关联在不同人群中是否一致。在 3079 名年龄大于 40 岁的参与者中,WtHR 与 ACC 之间存在负相关关系。在完全调整的模型中,WtHR 每增加 1 个单位,严重 AAC 的概率就会降低 2%(比值比=0.02,95%置信区间:[0.00-0.12])。与最低 quartile 相比,处于最高 quartile 的 WtHR 参与者发生严重 AAC 的可能性降低了 39%(比值比=0.61,95%置信区间:[0.37-1.00])。在糖尿病亚组中,这种负相关关系更为明显。我们发现,使用两阶段线性回归模型,WtHR 与 AAC 评分之间存在反 U 型关联,交点为 0.56。在美国成年人中,WtHR 与 AAC 呈负相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/11175898/7a2999827532/medi-103-e38608-g001.jpg

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