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当代持久机械循环支持的观点:我们在过去 3 年中学到了什么?

Contemporary Perspectives in Durable Mechanical Circulatory Support: What Did We Learn in the Last 3 Years?

机构信息

Division of Cardiology, University of Chicago, MC 2016, Rm A-621, 5841 S. Maryland Avenue, Chicago, IL, 60637-1470, USA.

出版信息

Curr Cardiol Rep. 2018 Jan 29;20(1):6. doi: 10.1007/s11886-018-0945-3.

DOI:10.1007/s11886-018-0945-3
PMID:29380144
Abstract

PURPOSE OF REVIEW

In this paper, we will review developments in the field of durable mechanical circulatory support over the past 3 years.

RECENT FINDINGS

The role of left ventricular assist device (LVAD) placement in non-inotrope-dependent ambulatory heart failure patients remains controversial in light of recent clinical trials. New devices are on the horizon for destination therapy in advanced heart failure patients. The concept of hemocompatibility and the calculation of hemocompatibility scores represent a novel approach to common adverse events. Recent research in mechanical circulatory support has impacted our approach to durable LVAD therapy and set the stage for further advancements in the field.

摘要

目的综述

本文将对过去 3 年机械循环支持领域的进展进行综述。

最近发现

鉴于最近的临床试验结果,左心室辅助装置(LVAD)在非正性肌力依赖型活动性心力衰竭患者中的应用作用仍存在争议。新设备即将问世,为晚期心力衰竭患者提供了终末期治疗的选择。血液相容性的概念和血液相容性评分的计算代表了一种处理常见不良事件的新方法。机械循环支持的最新研究改变了我们对耐用型 LVAD 治疗的方法,并为该领域的进一步发展奠定了基础。

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本文引用的文献

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Tumor necrosis factor-α levels and non-surgical bleeding in continuous-flow left ventricular assist devices.肿瘤坏死因子-α水平与连续流左心室辅助装置的非手术性出血。
J Heart Lung Transplant. 2018 Jan;37(1):107-115. doi: 10.1016/j.healun.2017.06.001. Epub 2017 Jun 8.
2
HVAD Waveform Analysis as a Noninvasive Marker of Pulmonary Capillary Wedge Pressure: A First Step Toward the Development of a Smart Left Ventricular Assist Device Pump.作为肺毛细血管楔压无创标志物的 HVAD 波形分析:迈向智能左心室辅助装置泵开发的第一步。
ASAIO J. 2018 Jan/Feb;64(1):10-15. doi: 10.1097/MAT.0000000000000604.
3
Assessing Frailty in Patients Undergoing Destination Therapy Left Ventricular Assist Device: Observations from Interagency Registry for Mechanically Assisted Circulatory Support.
评估接受目标治疗的左心室辅助装置患者的衰弱情况:来自机构间机械辅助循环支持注册中心的观察结果
ASAIO J. 2018 Jan/Feb;64(1):16-23. doi: 10.1097/MAT.0000000000000600.
4
The Hemodynamic Effects of Aortic Insufficiency in Patients Supported With Continuous-Flow Left Ventricular Assist Devices.主动脉瓣关闭不全对持续性左心室辅助装置支持患者血流动力学的影响。
J Card Fail. 2017 Jul;23(7):545-551. doi: 10.1016/j.cardfail.2017.04.012. Epub 2017 Apr 20.
5
Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients: The ROADMAP Study 2-Year Results.在门诊心力衰竭患者中左心室辅助装置和药物治疗的风险评估和比较效果:ROADMAP 研究 2 年结果。
JACC Heart Fail. 2017 Jul;5(7):518-527. doi: 10.1016/j.jchf.2017.02.016. Epub 2017 Apr 5.
6
Hemocompatibility-Related Outcomes in the MOMENTUM 3 Trial at 6 Months: A Randomized Controlled Study of a Fully Magnetically Levitated Pump in Advanced Heart Failure.MOMENTUM 3 试验 6 个月时的血液相容性相关结局:一种先进心力衰竭全磁悬浮泵的随机对照研究。
Circulation. 2017 May 23;135(21):2003-2012. doi: 10.1161/CIRCULATIONAHA.117.028303. Epub 2017 Apr 6.
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The burden of haemocompatibility with left ventricular assist systems: a complex weave.左心室辅助系统的血液相容性负担:一个复杂的交织情况。
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8
Intrapericardial Left Ventricular Assist Device for Advanced Heart Failure.经心室内左心室辅助装置治疗晚期心力衰竭。
N Engl J Med. 2017 Feb 2;376(5):451-460. doi: 10.1056/NEJMoa1602954.
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J Heart Lung Transplant. 2017 Jun;36(6):673-683. doi: 10.1016/j.healun.2016.12.010. Epub 2016 Dec 23.
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N Engl J Med. 2017 Feb 2;376(5):440-450. doi: 10.1056/NEJMoa1610426. Epub 2016 Nov 16.