National Institute for Optoelectronics, 409 Atomistilor St., Magurele, Romania. National Research Tomsk Polytechnic University, Lenin Avenue 43, Tomsk, 634050, Russia.
Biomed Mater. 2018 Jan 30;13(2):025011. doi: 10.1088/1748-605X/aa9718.
Hydroxyapatite (HAP) coatings are applied on metallic implant materials to combine mechanical properties of metallic material with bioactivity abilities of HAP ceramic. In this study, HAP coatings with additions of Si and Mg are proposed to be deposited on Ti6Al4V substrates by RF magnetron sputtering. Chemical bonding, morphology, topography and corrosion resistance in simulated body fluids (SBF) of the coatings were investigated. Additionally, mechanical and biological properties of the coatings were evaluated. It was found that the addition of Si and Mg does not influence the formation of a HAP phase. All the coatings exhibited smooth surface and uniform growth, without defects or cracks. Both hardness and elastic modulus of the coated samples decrease with Mg addition in the HAP-Si structure. Both Mg and Si addition into HAP coatings were found to enhance the corrosion resistance of the Ti6Al4V alloy in the SBF solution. Coatings with low Mg content exhibited better corrosion performance. All the coatings investigated were biocompatible, as demonstrated by SaOS-2 bone cell attachment and growth. However, cell proliferation and morphology were inferior on samples with the highest Mg content.
羟基磷灰石（HAP）涂层被应用于金属植入材料上，以结合金属材料的机械性能和 HAP 陶瓷的生物活性能力。在这项研究中，提出在 Ti6Al4V 基底上通过射频磁控溅射沉积添加 Si 和 Mg 的 HAP 涂层。研究了涂层的化学键合、形貌、形貌和在模拟体液（SBF）中的耐腐蚀性。此外，还评估了涂层的机械和生物学性能。结果发现，Si 和 Mg 的添加并不影响 HAP 相的形成。所有涂层均表现出光滑的表面和均匀的生长，没有缺陷或裂纹。HAP-Si 结构中添加 Mg 会降低涂层样品的硬度和弹性模量。在 SBF 溶液中，Mg 和 Si 的添加均能提高 Ti6Al4V 合金的耐腐蚀性。低 Mg 含量的涂层表现出更好的耐腐蚀性。所有研究的涂层均具有生物相容性，这可通过 SaOS-2 骨细胞附着和生长来证明。然而，在 Mg 含量最高的样品上，细胞增殖和形态较差。
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