几种醛脱氢酶和醛还原酶抑制剂对大鼠脑内二胺氧化酶的影响。

Influence of several aldehyde dehydrogenase and aldehyde reductase inhibitors on diamine oxidase in rat brain.

作者信息

Ruggeri P, Saija A, Costa G, Caputi A P

出版信息

Res Commun Chem Pathol Pharmacol. 1986 Feb;51(2):205-9.

Abstract

Pyrroline formation in rat brain was studied in presence of different inhibitors of AldDH, AldR, ADH and MAO. The inhibition of AldDH and AldR, but not of ADH and MAO significantly increased DAO activity. The results indicate that the use of appropriate aldehyde metabolizing enzymes inhibitors allows to better understand the role of diamine oxidase in rat brain putrescine catabolism.

摘要

在存在不同的醛脱氢酶（AldDH）、醛还原酶（AldR）、乙醇脱氢酶（ADH）和单胺氧化酶（MAO）抑制剂的情况下，对大鼠脑中吡咯啉的形成进行了研究。抑制醛脱氢酶和醛还原酶，但不抑制乙醇脱氢酶和单胺氧化酶，可显著提高二胺氧化酶（DAO）的活性。结果表明，使用合适的醛代谢酶抑制剂有助于更好地理解二胺氧化酶在大鼠脑腐胺分解代谢中的作用。