Kershengol'ts B M, Alekseev V G, Gavrilova E M, Li N G
Vopr Med Khim. 1985 Jan-Feb;31(1):47-51.
Dynamics of accumulation of alcohol- and aldehyde dehydrogenases inhibitors in liver tissue of rats with chronic alcohol intoxication showed that content of the bioinhibitors of protein nature was increased during the animals alcoholization, whereas inhibition of aldehyde dehydrogenase was more distinct as compared with alcohol dehydrogenase. When the nature of aldehyde dehydrogenase inhibitor was studied using the immunoenzyme analysis, the inhibitor proved to be an autoantibody, produced in chronic alcoholization of rats as a result apparently of the enzyme modification. Titre of specific antibodies to "autoantigen" (aldehyde dehydrogenase from liver tissue of alcohol consuming rats) was 12-16-fold higher in liver tissue and blood serum of rats with alcoholism as compared with the corresponding preparations of control animals. An immuno-enzymological mechanism, responsible for an increase of acetaldehyde content in blood developed after ethanol consumption in alcoholism, is discussed.
慢性酒精中毒大鼠肝组织中酒精脱氢酶和乙醛脱氢酶抑制剂的积累动态表明，在动物酒精化过程中，蛋白质性质的生物抑制剂含量增加，而与酒精脱氢酶相比，乙醛脱氢酶的抑制作用更为明显。当使用免疫酶分析法研究乙醛脱氢酶抑制剂的性质时，该抑制剂被证明是一种自身抗体，显然是在大鼠慢性酒精化过程中由于酶的修饰而产生的。与对照动物的相应制剂相比，酒精中毒大鼠肝组织和血清中针对“自身抗原”（来自饮酒大鼠肝组织的乙醛脱氢酶）的特异性抗体滴度高12 - 16倍。本文讨论了酒精中毒时乙醇摄入后血液中乙醛含量增加的免疫酶学机制。
