Active Carbohydrate Research Center, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China.
Active Carbohydrate Research Center, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China.
Int J Biol Macromol. 2018 Jun;112:211-216. doi: 10.1016/j.ijbiomac.2018.01.169. Epub 2018 Jan 31.
Polysaccharide is a kind of natural macromolecule polymer, which is widely existed in animals, plants and microorganisms, has a variety of biological activities, such as anti-tumor, anti-virus, anti-oxidation and immune regulation. Polysaccharides can affect macrophages, cells and other immune cells to improve the body's immune function, and have no toxic and side effects on normal cells, which make the polysaccharides receive widespread attention. In recent years, studies have shown that structural modification of polysaccharides can improve the immunological activity of polysaccharides. The common chemical modifications are sulfation, carboxymethylation, acetylation, phosphorylation, and so on. The chemical modification of polysaccharides and the immunomodulation of polysaccharides and polysaccharide derivatives were analyzed and discussed.
多糖是一种天然大分子聚合物，广泛存在于动物、植物和微生物中，具有多种生物活性，如抗肿瘤、抗病毒、抗氧化和免疫调节。多糖可以影响巨噬细胞、细胞等免疫细胞，提高机体的免疫功能，对正常细胞无毒副作用，这使得多糖受到广泛关注。近年来的研究表明，多糖的结构修饰可以提高多糖的免疫活性。常见的化学修饰有硫酸化、羧甲基化、乙酰化、磷酸化等。对多糖及其多糖衍生物的化学修饰与免疫调节作用进行了分析和探讨。
