Huang Gangliang, Chen Xin, Huang Hualiang
College of Chemistry, Chongqing Normal University, Chongqing, 401331, China.
Curr Drug Targets. 2016;17(15):1799-1803. doi: 10.2174/1389450117666160502151004.
The chemical modifications of polysaccharides involve the use of chemical methods to modify some special structures or functional groups of polysaccharides on the main chains or side chains. The chemical methods include sulfation, phosphorylation, acetylation, carboxymethylation etc. Therefore, spatial structures, and physical and chemical properties of polysaccharides change, which enhance the biological activities of polysaccharides, e.g., immune regulation, antivirus, anti-tumor, anti-oxidation, etc.
多糖的化学修饰是指利用化学方法对多糖主链或侧链上的一些特殊结构或官能团进行修饰。化学方法包括硫酸化、磷酸化、乙酰化、羧甲基化等。因此，多糖的空间结构以及物理和化学性质发生改变，从而增强了多糖的生物活性，如免疫调节、抗病毒、抗肿瘤、抗氧化等。
