重组人骨形态发生蛋白2促进骨再生的系统评价
Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review.
作者信息
de Queiroz Fernandes Jannice, de Lima Valthierre Nunes, Bonardi João Paulo, Filho Osvaldo Magro, Queiroz Sormani Bento Fernandes
机构信息
Quixadaense Post Graduate School, Rodrigues Junior Street, Number 1034, Quixadá, Ceara CEP 63900-000 Brazil.
2Department of Surgery and Clinic Integrated, Araçatuba Dental School-UNESP, José Bonifácio Street, Number 1193, Araçatuba, São Paulo CEP 16015-050 Brazil.
出版信息
J Maxillofac Oral Surg. 2018 Mar;17(1):13-18. doi: 10.1007/s12663-016-0988-1. Epub 2016 Dec 16.
Abstract
AIM
The aim of this work was to perform a systematic literature review on the clinical application of rhBMP-2 in bone reconstruction prior to placing implants.
MATERIALS AND METHODS
A PUBMED search was made about the subject and nine clinical trials were selected according to strict inclusion criteria.
RESULTS
Overall success rates of bone regeneration with rhBMP-2 was 81.4% and success of implants placed was 87.4%. Most frequent adverse events were pain, edema and erythema.
CONCLUSION
It was concluded that the treatment with rhBMP-2 foi satisfactory in most cases and the placement of dental implants in the bone regenerated with rhBMP-2 is feasible.
摘要
目的
本研究旨在对重组人骨形态发生蛋白-2（rhBMP-2）在种植体植入前骨重建中的临床应用进行系统的文献综述。
材料与方法
在PUBMED上对该主题进行检索，并根据严格的纳入标准选择了9项临床试验。
结果
rhBMP-2促进骨再生的总体成功率为81.4%，种植体植入成功率为87.4%。最常见的不良事件是疼痛、水肿和红斑。
结论
得出的结论是，rhBMP-2治疗在大多数情况下是令人满意的，并且在rhBMP-2再生的骨中植入牙种植体是可行的。
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