Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, New Delhi, India.
Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi- 110021, New Delhi, India.
Curr Drug Targets. 2018;19(15):1818-1830. doi: 10.2174/1389450119666180131105158.
Peroxisomal proliferator receptor gamma (PPARγ) is a class of nuclear hormone receptor family involved in insulin sensitization. In addition, PPARγ has a key role in the protection against oxidative stress and inflammation through regulation of NFkappaB levels and crosstalk with the Nrf2 pathway. Also, its role in the modulation of immune response is substantial.
Radiation-induced oxidative stress is the sole determinant of damage to hematopoietic, gastrointestinal system and immune system suppression. Uncontrolled exposure to normal cells during radiotherapy raises the demand for novel and efficient radioprotectors. In this review, we will present an overview of the involvement of PPARγ in radiation-induced damage and inflammation with major emphasis on whether PPARγ can serve as a suitable radiomodification target.
Through this review, we have justified that PPARγ having both radioprotective as wells as radiotherapeutic potential, may serve as an attractive target for the development of novel and more effective therapies.
过氧化物酶体增殖物激活受体 γ（PPARγ）是一类核激素受体家族，参与胰岛素敏感性。此外，PPARγ 通过调节 NFκB 水平和与 Nrf2 途径的相互作用，在抵抗氧化应激和炎症中起关键作用。此外，它在调节免疫反应方面也具有重要作用。
辐射诱导的氧化应激是导致造血、胃肠道系统和免疫系统抑制损伤的唯一决定因素。放射治疗过程中对正常细胞的失控暴露增加了对新型高效放射保护剂的需求。在这篇综述中，我们将概述 PPARγ 在辐射诱导损伤和炎症中的作用，重点讨论 PPARγ 是否可以作为合适的放射修饰靶点。
通过这篇综述，我们证明了 PPARγ 具有放射保护和放射治疗潜力，可能成为开发新型、更有效的治疗方法的有吸引力的靶点。
