Oury Julien, Oury Franck
Center for biology and medicine, Skirball institute of biomolecular medicine, New York university medical school, New York, 10016, États-Unis.
Inserm U1151, Institut Necker-Enfants Malades (INEM), Département Croissance et signalisation, équipe 14, université Paris Descartes Sorbone-Paris Cité, 14, rue Maria Helena Vieira Da Silva, 75014 Paris, France.
Med Sci (Paris). 2018 Jan;34(1):54-62. doi: 10.1051/medsci/20183401014. Epub 2018 Jan 31.
The maintenance of our physiological functions and their adaptive response to environmental changes depend on precise crosstalk between organs. Recent advances in mouse genetics have helped demonstrate that this holistic view of physiology extends to the skeletal system, where many unexpected signaling axes are found to play essential roles affecting numerous organs. After being long regarded as a static tissue, functioning merely as a structural support system, the skeleton has seen its image evolve into a much more complex picture. The skeleton reveals itself as a key endocrine organ for the homeostasis of our body, both by its central position in our body, but also by the large number of physiological functions it influences. In this review, we discuss the multiple endocrine roles of osteocalcin, an osteoclast-derived molecule (Ocn), where its functional importance has steadily increased over the last 15 years.
我们生理功能的维持及其对环境变化的适应性反应依赖于器官之间精确的相互作用。小鼠遗传学的最新进展有助于证明，这种生理学的整体观点也适用于骨骼系统，在该系统中发现许多意想不到的信号轴在影响众多器官方面发挥着重要作用。长期以来，骨骼一直被视为一种静态组织，仅作为结构支撑系统发挥作用，如今其形象已演变得更为复杂。骨骼不仅因其在人体中的中心位置，还因其影响的大量生理功能，而展现出自身作为人体稳态关键内分泌器官的特性。在本综述中，我们讨论了骨钙素（一种破骨细胞衍生分子，简称Ocn）的多种内分泌作用，在过去15年里其功能重要性一直在稳步增加。
