Wei Jianwen, Karsenty Gerard
Department of Genetics & Development, College of Physicians and Surgeons, Columbia University, 701W 168th Street, Room 1602A HHSC, New York, New York, 10032, USA.
Curr Osteoporos Rep. 2015 Jun;13(3):180-5. doi: 10.1007/s11914-015-0267-y.
A recent unexpected development of bone biology is that bone is an endocrine organ regulating a growing number of physiological processes. One of the functions regulated by bone through the hormone osteocalcin is glucose homeostasis. In this overview, we will explain why we hypothesized that bone mass and energy metabolism should be subjected to a coordinated endocrine regulation. We will then review the experiments that revealed the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We will also illustrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly, we will mention epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.
骨生物学领域最近出现了一个意外进展，即骨骼是一个内分泌器官，可调节越来越多的生理过程。骨骼通过激素骨钙素调节的功能之一是葡萄糖稳态。在本综述中，我们将解释我们为何假设骨量和能量代谢应受到协同的内分泌调节。然后，我们将回顾揭示骨钙素内分泌功能的实验以及使骨钙素成为一种激素的细胞生物学事件。我们还将阐述这种调节对于理解生理状态和病理状态下全身葡萄糖稳态的重要性。最后，我们将提及流行病学和遗传学证据，证明骨钙素的这一功能在人类中是保守的。
