Suchacki Karla J, Roberts Fiona, Lovdel Andrea, Farquharson Colin, Morton Nik M, MacRae Vicky E, Cawthorn William P
The Queen's Medical Research InstituteThe University of Edinburgh, Edinburgh, UK
The Roslin InstituteThe University of Edinburgh, Easter Bush, Midltohian, UK.
J Endocrinol. 2017 Jul;234(1):R67-R79. doi: 10.1530/JOE-17-0147. Epub 2017 Apr 28.
Throughout the last decade, significant developments in cellular, molecular and mouse models have revealed major endocrine functions of the skeleton. More recent studies have evolved the interplay between bone-specific hormones, the skeleton, marrow adipose tissue, muscle and the brain. This review focuses on literature from the last decade, addressing the endocrine regulation of global energy metabolism via the skeleton. In addition, we will highlight several recent studies that further our knowledge of new endocrine functions of some organs; explore remaining unanswered questions; and, finally, we will discuss future directions for this more complex era of bone biology research.
在过去十年中，细胞、分子和小鼠模型方面的重大进展揭示了骨骼的主要内分泌功能。最近的研究进一步阐明了骨特异性激素、骨骼、骨髓脂肪组织、肌肉和大脑之间的相互作用。本综述聚焦于过去十年的文献，探讨骨骼对全身能量代谢的内分泌调节作用。此外，我们将重点介绍一些最新研究，这些研究加深了我们对某些器官新内分泌功能的认识；探讨尚未解答的问题；最后，我们将讨论这个骨骼生物学研究更加复杂时代的未来发展方向。
