Petrosino M I, Scaparrotta A, Di Filippo P, Attanasi M, Di Pillo S, Chiarelli F, Mohn A
Department of Pediatrics, G. D'Annunzio University, Chieti, Italy.
Eur Ann Allergy Clin Immunol. 2018 May;50(3):99-107. doi: 10.23822/EurAnnACI.1764-1489.44. Epub 2017 Nov 24.
Food protein-induced enterocolitis syndrome (FPIES) is an under-recognized and frequently misdiagnosed non-IgE mediated food allergy syndrome. Affected infants show gastrointestinal symptoms few hours after ingestion of the incriminating food. Pathophysiology of FPIES has not yet been clearly defined and needs further characterization. The common allergy tests are not helpful for this disorder and tests for food specific IgE are usually negative. A diagnostic oral food challenge (OFC) is the method to confirm the diagnosis of FPIES. This review summarizes what is known about epidemiology, pathophysiology, clinical characteristics and diagnosis and what's new about therapeutic options of FPIES.
食物蛋白诱导的小肠结肠炎综合征（FPIES）是一种未得到充分认识且经常被误诊的非IgE介导的食物过敏综合征。受影响的婴儿在摄入致病食物后数小时会出现胃肠道症状。FPIES的病理生理学尚未明确界定，需要进一步明确特征。常见的过敏检测对这种疾病并无帮助，食物特异性IgE检测通常为阴性。诊断性口服食物激发试验（OFC）是确诊FPIES的方法。本综述总结了关于FPIES的流行病学、病理生理学、临床特征和诊断的已知信息，以及治疗选择方面的新进展。
