Jiang Guohua, Zhang Yinshun, Sun Xianjie
Department of Orthopedics, Zhejiang Rongjun Hospital, Jiaxing, Zhejiang Province Spine Orthopedics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, P.R. China.
Medicine (Baltimore). 2018 Feb;97(5):e9555. doi: 10.1097/MD.0000000000009555.
This study was conducted with the aim to investigate the relationship between Tetranectin (TN) and efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis.
Ninety-two patients with traumatic kyphosis admitted in our hospital from February 2014 to June 2016 were included whose serum TN levels were examined by ELISA. Using the mean level of TN as cut-off value, patients were classified into TN high level group (group I) and TN low level group (group II). The observation indexes, including operation time, intra-operational loss of blood, Cobb angle, postoperative complications and recurrence rate of kyphosis within post-operational 6 months were recorded for comparison.
TN level was significantly higher in group I [(6.19 ± 0.33) μmol/L] than that in group II [(5.29 ± 0.34) μmol/L] (P < .05). There was no significant difference in average age, sex, lesion site and average time from injury to operation between the two groups (all P > 0.05). Compared to group II, operation time in group I was significantly shortened (5.02 ± 1.15 VS 4.58 ± 0.53, P = .023), the intra-operational loss of blood decreased (2418.56 ± 362.06 VS 2235.84 ± 325.63, P = .013), post-operational Cobb angle decreased (11.10 ± 1.31 VS 6.93 ± 1.04, P = .000), and the incidence of postoperative complications (nail-breaking, rod-breaking and looseness) and recurrence rate decreased (18.8% VS 4.5%, P = .036; 10.4% VS 0.0%, P = .028).
Serum TN level is proved to be related to the efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis, and may serve as a possible indicator for clinical treatment.
本研究旨在探讨腱生蛋白（TN）与创伤性脊柱后凸患者后路脊柱V形截骨术疗效之间的关系。
纳入2014年2月至2016年6月在我院收治的92例创伤性脊柱后凸患者，采用酶联免疫吸附测定法检测其血清TN水平。以TN平均水平为界值，将患者分为TN高水平组（I组）和TN低水平组（II组）。记录观察指标，包括手术时间、术中失血量、Cobb角、术后并发症及术后6个月内脊柱后凸复发率，进行比较。
I组TN水平[（6.19±0.33）μmol/L]显著高于II组[（5.29±0.34）μmol/L]（P<0.05）。两组患者的平均年龄、性别、病变部位及受伤至手术的平均时间比较，差异均无统计学意义（均P>0.05）。与II组相比，I组手术时间显著缩短（5.02±1.15对4.58±0.53，P=0.023），术中失血量减少（2418.56±362.06对2235.84±325.63，P=0.013），术后Cobb角减小（11.10±1.31对6.93±1.04，P=0.000），术后并发症（断钉、断棒及松动）发生率及复发率降低（18.8%对4.5%，P=0.036；10.4%对0.0%，P=0.028）。
血清TN水平与创伤性脊柱后凸患者后路脊柱V形截骨术疗效相关，可能作为临床治疗的一个潜在指标。
