Song Hyun-Seop, Shin Joon-Shik, Lee Jinho, Lee Yoon Jae, Kim Me-Riong, Cho Jae-Heung, Kim Koh-Woon, Park Yeoncheol, Song Hyun Jin, Park Sun-Young, Kim Seoyoun, Kim Mia, Ha In-Hyuk
Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul, Republic of Korea.
Department of Korean Rehabilitation Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
PLoS One. 2018 Jan 31;13(1):e0191336. doi: 10.1371/journal.pone.0191336. eCollection 2018.
Temporomandibular disorders (TMDs) are common musculoskeletal conditions in the maxillofacial area. Although strong relationships between TMDs and other pain and diseases exist, few studies have comprehensively assessed the association between chronic diseases, ophthalmologic and otolaryngologic disorders and TMD.
Of 25,534 individuals included in the fifth Korea National Health and Nutrition Examination Survey (2010-2012), 17,575 aged ≥20 years who completed survey items on TMD symptoms were included for cross-sectional analysis. Logistic regression analysis was performed to assess the association between chronic diseases, ophthalmologic and otolaryngologic disorders and examination findings, and TMD symptoms after adjusting for various confounding variables.
Out of 17,575 participants, 2,059 (11.75%) reported experience of ≥1 TMD symptom(s). Compared to individuals without chronic disease, those with asthma (odds ratio (OR) 1.46; 95% confidence interval (CI) 1.09-1.96), migraine (1.44; 1.26-1.65), osteoarthritis (1.51; 1.20-1.89), thyroid dysfunction (1.49; 1.13-1.96), and depressive symptoms (1.51; 1.29-1.77) had higher ORs for TMD prevalence. Participants with tinnitus (1.97; 1.70-2.27), hearing difficulties (1.55; 1.29-1.87), dizziness (1.52; 1.27-1.82), rhinitis (1.46; 1.28-1.65), and xerophthalmia (1.82; 1.57-2.12) also displayed higher ORs for TMD prevalence. Patients diagnosed with chronic rhinosinusitis upon otolaryngologic examination exhibited an OR of 1.44 (95% CI 1.11-1.87) for TMD prevalence, while that for individuals with abnormal laryngoscopic results was 0.57 (95% CI 0.36-0.90).
These findings imply that TMDs, chronic diseases, and ophthalmologic and otolaryngologic disorders hold various correlations, suggesting the need for multitarget approaches to effectively address this phenomenon.
颞下颌关节紊乱病(TMDs)是颌面区域常见的肌肉骨骼疾病。尽管TMDs与其他疼痛和疾病之间存在密切关系,但很少有研究全面评估慢性病、眼科和耳鼻喉科疾病与TMD之间的关联。
在第五次韩国国家健康与营养检查调查(2010 - 2012年)纳入的25,534名个体中,17,575名年龄≥20岁且完成了TMD症状调查项目的个体被纳入横断面分析。进行逻辑回归分析,以评估在调整各种混杂变量后,慢性病、眼科和耳鼻喉科疾病及检查结果与TMD症状之间的关联。
在17,575名参与者中,2,059名(11.75%)报告有≥1种TMD症状。与无慢性病的个体相比,患有哮喘(优势比(OR)1.46;95%置信区间(CI)1.09 - 1.96)、偏头痛(1.44;1.26 - 1.65)、骨关节炎(1.51;1.20 - 1.89)、甲状腺功能障碍(1.49;1.13 - 1.96)和抑郁症状(1.51;1.29 - 1.77)的个体TMD患病率的OR值更高。有耳鸣(1.97;1.70 - 2.27)、听力困难(1.55;1.29 - 1.87)、头晕(1.52;1.27 - 1.82)、鼻炎(1.46;1.28 - 1.65)和干眼症(1.82;1.57 - 2.12)的参与者TMD患病率的OR值也更高。经耳鼻喉科检查诊断为慢性鼻窦炎的患者TMD患病率的OR值为1.44(95% CI 1.11 - 1.87),而喉镜检查结果异常的个体的OR值为0.57(95% CI 0.36 - 0.90)。
这些发现表明TMDs、慢性病以及眼科和耳鼻喉科疾病之间存在多种关联,这表明需要采取多靶点方法来有效应对这一现象。