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有口面部不适症状患者的耳鸣

Tinnitus in patients with orofacial complaints.

作者信息

Peter Nicole, Serventi Jasmine, Neff Patrick, Ettlin Dominik, Wojczyńska Aleksandra Zumbrunn, Kleinjung Tobias, Lukic Nenad

机构信息

Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.

出版信息

Head Face Med. 2025 Apr 25;21(1):31. doi: 10.1186/s13005-025-00505-w.


DOI:10.1186/s13005-025-00505-w
PMID:40281572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12032725/
Abstract

BACKGROUND: This study explored subjective tinnitus frequency in patients referred to an interdisciplinary orofacial pain clinic using the "web-based interdisciplinary symptom evaluation" (WISE) tool, which included a wide range of psychometric data. Our goal was to analyze the correlation between orofacial complaints and tinnitus, as well as their association with other psychometric data-an approach that, to our knowledge, has not been undertaken to this extent before. METHODS: From 2017 to 2020, we analyzed 1369 anonymized patient records using completed WISE. This included diverse questionnaires and symptom-related screener questions. Positive screening responses triggered additional assessments, such as short Tinnitus Handicap Inventory (THI-12) and Patient Health Questionnaire 4 (PHQ-4). Ear symptoms, tinnitus severity and tinnitus frequency were evaluated. Furthermore, Spearman correlations were performed with other questionnaires addressing pain, anxiety, depression, health, stress and insomnia. RESULTS: Among 1369 patients with orofacial complaints, 69% were female. Notably, 19.7% (269) completed THI-12 due to severe ear symptoms; of these, 62.1% were female. Female mean THI-12 score was significantly lower (p = 0.007) with 9.3 (SD = 7.0) compared to males 11.6 (SD = 6.8). Additionally, there was a significantly different gender distribution between all patients with tinnitus and those with severe tinnitus (p = 0.032), with an increased proportion of men in the latter group. THI-12 positively correlated with all WISE questionnaires, strongest with PHQ-4 (p < 0.01). CONCLUSIONS: Our study unveils a common co-occurrence of orofacial and ear complaints, particularly tinnitus. The practical implication of the observed gender differences suggests that in male patients presenting with orofacial pain, tinnitus and its associated distress should be actively addressed to initiate a multidisciplinary treatment approach. CLINICAL TRIAL NUMBER: Not applicable. Since this study was a retrospective analysis of anonymized data, trial registration was not necessary.

摘要

背景:本研究使用“基于网络的跨学科症状评估”(WISE)工具,对转诊至跨学科口腔面部疼痛诊所的患者的主观性耳鸣频率进行了探索,该工具包含了广泛的心理测量数据。我们的目标是分析口腔面部疼痛与耳鸣之间的相关性,以及它们与其他心理测量数据的关联——据我们所知,此前尚未在如此程度上进行过此类研究。 方法:2017年至2020年期间,我们对1369份使用完整WISE的匿名患者记录进行了分析。这包括各种问卷和与症状相关的筛查问题。阳性筛查反应会引发额外评估,如简短耳鸣障碍量表(THI - 12)和患者健康问卷4(PHQ - 4)。对耳部症状、耳鸣严重程度和耳鸣频率进行了评估。此外,还与其他涉及疼痛、焦虑、抑郁、健康、压力和失眠的问卷进行了Spearman相关性分析。 结果:在1369例有口腔面部疼痛的患者中,69%为女性。值得注意的是,19.7%(269例)因严重耳部症状完成了THI - 12;其中,62.1%为女性。女性的THI - 12平均得分显著更低(p = 0.007),为9.3(标准差 = 7.0),而男性为11.6(标准差 = 6.8)。此外,所有耳鸣患者与严重耳鸣患者之间的性别分布存在显著差异(p = 0.032),后一组男性比例增加。THI - 12与所有WISE问卷呈正相关,与PHQ - 4的相关性最强(p < 0.01)。 结论:我们的研究揭示了口腔面部和耳部症状,尤其是耳鸣的共同出现。观察到的性别差异的实际意义表明,对于出现口腔面部疼痛的男性患者,应积极处理耳鸣及其相关困扰,以启动多学科治疗方法。 临床试验编号:不适用。由于本研究是对匿名数据的回顾性分析,无需进行试验注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a38b/12032725/33b66ac00dc9/13005_2025_505_Fig7_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a38b/12032725/ee8b98bbaef6/13005_2025_505_Fig1_HTML.jpg
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引用本文的文献

[1]
In patients' words: natural language processing of reports from patients experiencing orofacial pain and dysfunction.

J Headache Pain. 2025-7-30

本文引用的文献

[1]
Associations between temporomandibular disorders and tinnitus - a systematic review.

Cranio. 2024-9-17

[2]
Clinical profile in relation to age and gender of patients with temporomandibular disorders: a retrospective study.

BMC Oral Health. 2024-8-16

[3]
Treatment approaches, outcomes and prognostic indicators in patients with tinnitus and temporomandibular disorders evaluated with DC/TMD: A systematic review and Meta-analysis.

J Oral Rehabil. 2025-2

[4]
Dental patients' tinnitus profile: prevalence, types, and associated factors with oral and maxillofacial diseases.

Acta Odontol Scand. 2024-4-29

[5]
A Meta-Analysis of the Global Prevalence of Temporomandibular Disorders.

J Clin Med. 2024-2-28

[6]
The correlation between tinnitus-specific and quality of life questionnaires to assess the impact on the quality of life in tinnitus patients.

Front Neurol. 2022-9-26

[7]
Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis.

JAMA Neurol. 2022-9-1

[8]
Tinnitus prevalence in Europe: a multi-country cross-sectional population study.

Lancet Reg Health Eur. 2021-11-4

[9]
[German-language versions of the Tinnitus Functional Index : Comparison of the two validated German-language versions of the Tinnitus Functional Index for Switzerland and Germany].

HNO. 2022-3

[10]
Auditory thalamus dysfunction and pathophysiology in tinnitus: a predictive network hypothesis.

Brain Struct Funct. 2021-7

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