Department of Health Sciences, Karlstad University, Karlstad, Sweden.
School of Medical Sciences, Örebro University, Örebro, Sweden.
Acta Paediatr. 2018 Jun;107(6):1011-1019. doi: 10.1111/apa.14245. Epub 2018 Feb 22.
This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants.
From 2007 to 2010, we used liquid chromatography-tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders.
There were significant associations between phthalate metabolites of butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose-response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life.
Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.
本研究旨在探讨产前邻苯二甲酸酯暴露是否与婴儿的上呼吸道或下呼吸道炎症有关。
2007 年至 2010 年，我们使用液相色谱-串联质谱法，经肌酐校正后，分析了 1062 名瑞典孕妇在妊娠 10 周时的尿液中的 14 种邻苯二甲酸酯代谢物和 1 种邻苯二甲酸酯替代物。采用逻辑回归法，调整潜在混杂因素后，我们根据产前邻苯二甲酸酯暴露情况与婴儿在 12 个月龄前发生喘鸣、喘息或中耳炎之间的关系进行了分析。
在调整了潜在混杂因素后，母体产前尿液中 BBzP 和 DEHP 邻苯二甲酸酯代谢物浓度与 1062 名婴儿在生命第一年的喘鸣之间存在显著相关性。产前邻苯二甲酸酯暴露与儿童报告的母亲喘鸣之间存在剂量反应关系，且在男孩中具有显著相关性。但产前邻苯二甲酸酯暴露与儿童在生命第一年的喘息或中耳炎之间没有明确的关联迹象。
我们的分析表明，暴露于 BBzP 和 DEHP 邻苯二甲酸酯与婴儿在 12 个月龄前出现母亲报告的喘鸣有关。
