在一项为期 9 年的随访出生队列研究中：台湾母婴队列研究，产前和儿童期接触邻苯二甲酸酯二酯与甲状腺功能。
Prenatal and Childhood Exposure to Phthalate Diesters and Thyroid Function in a 9-Year Follow-up Birth Cohort Study: Taiwan Maternal and Infant Cohort Study.
机构信息
From the aSchool of Public Health, National Defense Medical Center, Taipei, Taiwan; bNational Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; cDepartment of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan; dDepartment of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; eDepartment of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; fResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; and gDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
出版信息
Epidemiology. 2017 Oct;28 Suppl 1:S10-S18. doi: 10.1097/EDE.0000000000000722.
BACKGROUND
Phthalates are widely used in industry, personal care products, and medications. Recent studies have suggested that phthalate exposure alters thyroid hormones. However, longitudinal studies concerning the association between phthalate exposure and thyroid function in children are scant. Therefore, we examined the association between pre- and postnatal phthalate exposure and thyroid function in children born in 2000-2001.
METHODS
We studied 181 mother-child pairs in central Taiwan and followed-up the children from 2000 to 2009 at 2, 5, and 8 years old. We measured serum levels of thyroxine (T4), free T4, triiodothyronine (T3), and thyroid-stimulating hormone in children by using radioimmunoassay. We quantified seven phthalate metabolites, representing the five most commonly used phthalates, in maternal and child urine samples by using liquid chromatography-tandem mass spectrometry. The metabolites were monoethylhexyl phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) derived from di(2-ethylhexyl) phthalate (DEHP), monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), and monobenzyl phthalate (MBzP). We constructed a linear mixed model to examine these associations after adjustments for covariates.
RESULTS
The T4 levels were inversely associated with maternal urinary MEHHP (β = -0.028 [95% confidence interval (CI) = -0.051, -0.006]) and MEOHP (β = -0.027 [-0.050, -0.003]), with similar T3 levels being observed in boys, even when the children exposure levels were considered spontaneously. In the girls, the free T4 levels were inversely associated with levels of maternal urinary MEP (β = -0.042), maternal urinary MBzP (β = -0.050), and children's urinary MEHP (β = -0.027).
CONCLUSIONS
Early life phthalate exposure was associated with decreased thyroid hormone levels in young children.
背景
邻苯二甲酸酯广泛应用于工业、个人护理产品和药物中。最近的研究表明，邻苯二甲酸酯暴露会改变甲状腺激素。然而，关于儿童邻苯二甲酸酯暴露与甲状腺功能之间的纵向研究很少。因此，我们研究了 2000-2001 年出生的儿童在产前和产后邻苯二甲酸酯暴露与甲状腺功能之间的关系。
方法
我们在台湾中部研究了 181 对母婴对，并在 2000 年至 2009 年期间对儿童进行了 2 岁、5 岁和 8 岁的随访。我们使用放射免疫法测量儿童血清中甲状腺素（T4）、游离 T4、三碘甲状腺原氨酸（T3）和甲状腺刺激激素的水平。我们使用液相色谱-串联质谱法对母亲和儿童尿液样本中的七种邻苯二甲酸酯代谢物（代表五种最常用的邻苯二甲酸酯）进行定量。这些代谢物分别为邻苯二甲酸二（2-乙基己基）酯（DEHP）衍生的单乙基己基邻苯二甲酸酯（MEHP）、单（2-乙基-5-羟基己基）邻苯二甲酸酯（MEHHP）、单（2-乙基-5-氧代己基）邻苯二甲酸酯（MEOHP）、单甲基邻苯二甲酸酯（MMP）、单乙基邻苯二甲酸酯（MEP）、单丁基邻苯二甲酸酯（MBP）和单苄基邻苯二甲酸酯（MBzP）。我们构建了一个线性混合模型，以在调整协变量后检验这些关联。
结果
T4 水平与母体尿液中 MEHHP（β=-0.028[95%置信区间（CI）=-0.051，-0.006]）和 MEOHP（β=-0.027[-0.050，-0.003]）呈负相关，男孩的 T3 水平也观察到类似的变化，即使考虑到儿童的暴露水平也是如此。在女孩中，游离 T4 水平与母体尿液中 MEP（β=-0.042）、母体尿液中 MBzP（β=-0.050）和儿童尿液中 MEHP（β=-0.027）呈负相关。
结论
儿童早期邻苯二甲酸酯暴露与甲状腺激素水平降低有关。
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