Department of Pharmacy, University of California Davis Medical Center, Sacramento, CA, USA.
Department of Medical Microbiology and Immunology, University of California-Davis, Davis, CA, USA.
Mycoses. 2018 May;61(5):337-339. doi: 10.1111/myc.12749. Epub 2018 Feb 15.
We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.
我们描述了一例伊曲康唑治疗继发的明显盐皮质激素过多症（高血压、低血钾、代谢性碱中毒和低血浆肾素活性）。证明存在 11β-羟类固醇脱氢酶 2 的抑制作用，停用伊曲康唑后不良作用得到缓解，且未再使用伏立康唑复发。该报告增加了越来越多的证据表明某些三唑类药物与明显盐皮质激素过多症有关。
