Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.02130-17. Print 2018 May.
A woman in her late 60s with disseminated histoplasmosis was treated with posaconazole because first-line therapies were not tolerated. She subsequently presented with decompensated heart failure, hypertension, and hypokalemia. Laboratory tests revealed low renin and aldosterone levels. A potential mechanism is inhibition of the enzyme 11β-hydroxysteroid dehydrogenase 2, with resultant apparent mineralocorticoid excess.
一位 60 多岁的女性患有播散性组织胞浆菌病，因无法耐受一线治疗而接受泊沙康唑治疗。随后，她出现心力衰竭失代偿、高血压和低钾血症。实验室检查显示肾素和醛固酮水平低。潜在的机制是抑制酶 11β-羟甾类脱氢酶 2，导致皮质醇样物质过多。
