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加拿大与美国髋部骨折修复术后患者的预后比较:FOCUS试验的二次分析

A comparison of outcomes between Canada and the United States in patients recovering from hip fracture repair: secondary analysis of the FOCUS trial.

作者信息

Beaupre Lauren A, Wai Eugene K, Hoover Donald R, Noveck Helaine, Roffey Darren M, Cook Donald R, Magaziner Jay S, Carson Jeffrey L

机构信息

Department of Physical Therapy, University of Alberta, Edmonton, Alberta, Canada.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada.

出版信息

Int J Qual Health Care. 2018 Mar 1;30(2):97-103. doi: 10.1093/intqhc/mzx199.

Abstract

OBJECTIVE

To determine if adjusted mortality, walking ability or return home differed after hip fracture surgery between Canada and the USA.

DESIGN

Secondary analysis of the Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS) trial data.

SETTING

Data were collected from 47 American and Canadian hospitals.

PARTICIPANTS

Overall, 2016 subjects with a hip fracture (USA = 1222 (60.6%); Canada = 794 (39.4%)) were randomized to a liberal or restrictive transfusion strategy. Subjects were 50 years and older, with cardiovascular disease and/or risk factors and hemoglobin <100 g/L within 3 days post-surgery. The average age was 82 years and 1527(76%) subjects were females.

INTERVENTION

Demographics, health status and health services data were collected up to 60 days post-surgery and mortality to a median of 3 years post-surgery.

MAIN OUTCOMES

Mortality, inability to walk and return home.

RESULTS

US subjects had higher adjusted mortality than Canadians at 30 days (odds ratio = 1.78; 95% confidence interval: 1.09-2.90), 60 days (1.53; 1.02-2.29) and up to 3 years (hazard ratio = 1.25; 1.07-1.45). There were no differences in adjusted outcomes for walking ability or return home at 30 or 60 days post-surgery. Median hospital length of stay was longer (P < 0.0001) in Canada (9 days; interquartile range: 5-18 days) than the US (3 days; 2-5 days). US subjects (52.9%) were more likely than Canadians (16.8%) to be discharged to nursing homes for rehabilitation (P < 0.001).

CONCLUSIONS

Adjusted survival favored Canadians post hip fracture while walking ability and return home were not different between countries. The reason(s) for mortality differences warrant further investigation.

摘要

目的

确定加拿大和美国髋部骨折手术后调整后的死亡率、行走能力或回家情况是否存在差异。

设计

对接受髋部骨折手术修复的心血管患者功能结局(FOCUS)试验数据进行二次分析。

设置

数据收集自47家美国和加拿大医院。

参与者

总体而言,2016例髋部骨折患者(美国 = 1222例(60.6%);加拿大 = 794例(39.4%))被随机分配至宽松或限制性输血策略组。受试者年龄在50岁及以上,患有心血管疾病和/或风险因素,且术后3天内血红蛋白<100 g/L。平均年龄为82岁,1527例(76%)受试者为女性。

干预

收集术后60天内的人口统计学、健康状况和卫生服务数据,以及术后至3年中位数的死亡率。

主要结局

死亡率、无法行走和回家情况。

结果

美国受试者在术后30天(比值比 = 1.78;95%置信区间:1.09 - 2.90)、60天(1.53;1.02 - 2.29)及长达3年(风险比 = 1.25;1.07 - 1.45)时的调整后死亡率高于加拿大受试者。术后30天或60天时,行走能力或回家情况的调整后结局无差异。加拿大的中位住院时间(9天;四分位间距:5 - 18天)比美国(3天;2 - 5天)更长(P < 0.0001)。美国受试者(52.9%)比加拿大受试者(16.8%)更有可能被送往疗养院进行康复治疗(P < 0.001)。

结论

髋部骨折后调整后的生存率加拿大受试者更优,而两国之间的行走能力和回家情况并无差异。死亡率差异的原因值得进一步研究。

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