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良性和恶性涎腺肿瘤中的性激素受体：预后和预测作用。

Sex Hormone Receptors in Benign and Malignant Salivary Gland Tumors: Prognostic and Predictive Role.

机构信息

Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale", IRCCS, Naples 80131, Italy.

Head and Neck Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione G. Pascale", IRCCS, Naples, 80131, Italy.

出版信息

Int J Mol Sci. 2018 Jan 30;19(2):399. doi: 10.3390/ijms19020399.

DOI:10.3390/ijms19020399
PMID:29385707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5855621/
Abstract

The role of sex hormone receptors in human cancer development and progression has been well documented in numerous studies, as has the success of sex hormone antagonists in the biological therapy of many human tumors. In salivary gland tumors (SGTs), little and conflicting information about the role of the estrogen receptor alpha (ERα), progesterone receptor (PgR) and androgen receptor (AR) has been described and in most cases the use of sex hormone antagonists is not contemplated in clinical practice. In this study, we analyzed a panel of sex hormone receptors that have not been widely investigated in SGTs-ERα, PgR, AR, but also ERβ and GPR30-to define their expression pattern and their prognostic and predictive value in a case series of 69 benign and malignant SGTs. We showed the aberrant expression of AR in mucoepidermoid and oncocytic carcinoma, a strong relation between cytoplasmic ERβ expression and tumor grade, and a strong correlation between nuclear GPR30 expression and disease-free survival (DFS) of SGT patients.

摘要

在许多研究中已经充分证明了性激素受体在人类癌症发展和进展中的作用，以及性激素拮抗剂在许多人类肿瘤的生物治疗中的成功。在唾液腺肿瘤（SGT）中，关于雌激素受体α（ERα）、孕激素受体（PgR）和雄激素受体（AR）作用的信息很少且相互矛盾，在大多数情况下，临床实践中不考虑使用性激素拮抗剂。在这项研究中，我们分析了一组在 SGT 中尚未广泛研究的性激素受体-ERα、PgR、AR，但也包括 ERβ 和 GPR30-以确定它们在 69 例良性和恶性 SGT 病例系列中的表达模式及其预后和预测价值。我们显示了 AR 在黏液表皮样癌和嗜酸细胞瘤中的异常表达，细胞质 ERβ 表达与肿瘤分级之间存在很强的关系，核 GPR30 表达与 SGT 患者无病生存（DFS）之间存在很强的相关性。

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