Department of Oral Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
J Oral Pathol Med. 2013 Oct;42(9):716-9. doi: 10.1111/jop.12071. Epub 2013 Apr 19.
The mammary and salivary glands are tubulo-acinar exocrine glands, sharing similar morphological characteristics and tumour histology. It is logical to postulate that they may have similar tumour biology. This study was carried out to define the expression of oestrogen-α (ER-α) and progesterone (PR) in salivary gland tumours (SGTs) presenting at the University College Hospital, Ibadan.
Formalin-fixed, paraffin-embedded tissue samples of different salivary gland neoplasms were processed for antibodies to ER-α and PR using the specifications of the manufacturer. Two independent investigators reviewed the slides scoring the pattern and intensity of staining as follows: negative (0), weakly positive (+1), moderately positive (+2) and strongly positive (+3). Data were analysed using version 16 of the Statistical Package for Social Sciences (SPSS16). The level of significance was set at P < 0.05.
A total of 40 SGTs from 19 males (47.5%) and 21 females (52.5%) were utilised. There were 15 benign and 25 malignant SGTs. ER expression in benign SGTs was 6.7%, while in malignant SGTs, it was 28.0%. There was no statistically significant difference in the gender and mean age distribution between patients with or without positive ER-α expression (χ(2) = 0.37, P = 0.59 Fisher's exact test; t = 0.054, P = 0.96, respectively). About 66.7% of high-grade SGTs was positive for ER while only 20% of the low-grade lesions were positive.
This study showed that ER-α was expressed more in the high-grade malignant SGTs compared with the low-grade malignant SGTs and the benign SGTs.
乳腺和唾液腺均为管状-泡状外分泌腺，具有相似的形态学特征和肿瘤组织学。因此，我们可以合理地推测它们可能具有相似的肿瘤生物学特性。本研究旨在确定在伊巴丹大学教学医院就诊的唾液腺肿瘤（SGT）中雌激素-α（ER-α）和孕激素（PR）的表达情况。
使用制造商的说明书，对福尔马林固定、石蜡包埋的不同唾液腺肿瘤组织样本进行 ER-α 和 PR 抗体处理。两名独立的研究者对切片进行回顾，对染色模式和强度进行评分，评分标准如下：阴性（0）、弱阳性（+1）、中度阳性（+2）和强阳性（+3）。使用社会科学统计软件包（SPSS16）的第 16 版对数据进行分析。显著性水平设置为 P < 0.05。
共使用了 19 名男性（47.5%）和 21 名女性（52.5%）的 40 例 SGT 患者。良性 SGT 有 15 例，恶性 SGT 有 25 例。良性 SGT 的 ER 表达率为 6.7%，而恶性 SGT 的 ER 表达率为 28.0%。ER-α 阳性表达患者与阴性表达患者在性别和平均年龄分布方面无统计学差异（卡方检验：χ²=0.37，P=0.59；Fisher 确切概率检验：χ²=0.37，P=0.59；t 检验：t=0.054，P=0.96）。高分级 SGT 中约有 66.7%为 ER 阳性，而低分级病变中仅有 20%为 ER 阳性。
本研究表明，与低分级恶性 SGT 和良性 SGT 相比，高分级恶性 SGT 中 ER-α 的表达更为常见。
