Jafari Najmeh, Mahmoudi Seyed Mostafa, Akhavan Tafti Mahmood, Sabaghzadegan Farinaz
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Social Determinant of Oral Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Dent (Shiraz). 2025 Sep 1;26(3):220-225. doi: 10.30476/dentjods.2024.102344.2356. eCollection 2025 Sep.
Progesterone (PR) plays a role in the differentiation and growth of various tissues. One of the most common carcinogenic mechanisms of PR is increasing cell proliferation and inhibiting their apoptosis. There are contradictory results from various studies about the expression level of PR receptors in salivary tumors.
Considering the sporadic studies and the contradictory results, this study was conducted to determine the expression level of PR receptor in the most common benign and malignant salivary gland tumors.
In this descriptive cross-sectional study, 58 paraffinized blocks (36 pleomorphic adenoma samples and 22 mucoepidermoid carcinoma samples) were selected. PR receptor immunohistochemical staining was performed on the samples and the resulting slides were examined under a light microscope with 100x magnification. The gleaned data were analyzed with SPSS25 using descriptive statistics, Fisher's exact test, and Chi-square test.
Out of 36 pleomorphic adenoma samples, one sample expressed PR receptor moderately and two expressed it weakly. Besides, out of 22 mucoepidermoid carcinoma samples, only one sample expressed PR receptor. The comparison of PR receptor expression between two groups was not statistically significant ( Value=0.719).
Based on the findings of this study, it can be concluded that PR receptor cannot probably play a direct role in carcinogenesis and prognosis of benign and malignant salivary tumors.
孕酮（PR）在多种组织的分化和生长中发挥作用。PR最常见的致癌机制之一是增加细胞增殖并抑制其凋亡。关于唾液腺肿瘤中PR受体的表达水平，各种研究结果相互矛盾。
鉴于相关研究较为零散且结果相互矛盾，本研究旨在确定最常见的良性和恶性唾液腺肿瘤中PR受体的表达水平。
在这项描述性横断面研究中，选取了58个石蜡包埋块（36个多形性腺瘤样本和22个黏液表皮样癌样本）。对样本进行PR受体免疫组织化学染色，并在100倍放大的光学显微镜下检查所得玻片。使用SPSS25对收集到的数据进行描述性统计、Fisher精确检验和卡方检验分析。
在36个多形性腺瘤样本中，1个样本PR受体呈中度表达，2个样本呈弱表达。此外，在22个黏液表皮样癌样本中，只有1个样本表达PR受体。两组之间PR受体表达的比较无统计学意义（值 = 0.719）。
基于本研究结果，可以得出结论，PR受体可能不会在良性和恶性唾液腺肿瘤的致癌作用和预后中发挥直接作用。
