1 RIVM, Bilthoven, the Netherlands.
2 DKFZ, Heidelberg, Germany.
Lab Anim. 2018 Jun;52(3):300-303. doi: 10.1177/0023677218754597. Epub 2018 Jan 31.
Pasteurellosis is a well-recognized disease with similar pathology in all laboratory rodent species. Pasteurella pneumotropica is the most frequently mentioned member of the Pasteurellaceae isolated from mice and rats. Numerous other Pasteurellaceae taxa have been obtained from mice, rats, and other rodent species. Recently, rodent Pasteurellaceae have been submitted to comprehensive genetic and phenotypic (polyphasic) taxonomic studies. As a result they are now classed within six validly published new genera, namely Cricetibacter, Mesocricetibacter, Mannheimia, Muribacter, Necropsobacter, and Rodentibacter. All previously used names such as P. pneumotropica have become obsolete. The new classification forms a firm basis for the correct phenotypic identification of Pasteurellaceae from laboratory animals and for the selection of strains for pathogenicity studies. Consequences of taxonomic changes notably involve molecular methods used for the detection of Pasteurellaceae infection in laboratory animal colonies. Testing may be done using primer sets that detect all Pasteurellaceae taxa or sets developed to detect host-specific members of the family.
巴斯德氏菌病是一种公认的疾病，所有实验室啮齿动物物种都具有相似的病理学特征。从鼠和大鼠中分离出的巴斯德氏菌科中，最常提到的成员是豚鼠巴斯德氏菌。从鼠、大鼠和其他啮齿动物物种中还获得了许多其他巴斯德氏菌科分类群。最近，啮齿动物巴斯德氏菌科已提交给全面的遗传和表型（多相）分类学研究。结果，它们现在被归类为六个有效发表的新属，即 Cricetibacter、Mesocricetibacter、曼海姆菌、Muribacter、Necropsobacter 和 Rodentibacter。所有以前使用的名称，如豚鼠巴斯德氏菌，已成为过时的名称。新的分类为正确表型鉴定来自实验动物的巴斯德氏菌科以及选择用于致病性研究的菌株提供了坚实的基础。分类变化的后果特别涉及用于检测实验动物群体中巴斯德氏菌科感染的分子方法。可以使用检测所有巴斯德氏菌科分类群的引物组或为检测家族中宿主特异性成员而开发的组进行测试。
