Shimokawa Jun
Graduate School of Pharmaceutical Sciences, Nagoya University.
Chem Pharm Bull (Tokyo). 2018;66(2):105-115. doi: 10.1248/cpb.c17-00819.
The divergent total syntheses of three types of heteropolycyclic natural products, namely gelsedine-type alkaloids, amathaspiramide alkaloids, and erythrina alkaloids, are outlined. A strategy involving a late-stage pluripotent common synthetic intermediate prepared via original and innovative transformations was employed. A brief description of the philosophy and criteria for choosing the synthetic targets and common synthetic precursors, as well as details regarding the development of the overall synthetic schemes from a common intermediate are discussed.
概述了三种杂环天然产物的不同全合成方法，即格塞定型生物碱、阿玛他斯皮拉米德生物碱和刺桐生物碱。采用了一种策略，该策略涉及通过原始和创新转化制备的后期多能通用合成中间体。讨论了选择合成目标和通用合成前体的理念和标准的简要描述，以及从通用中间体开发整体合成方案的详细信息。
