喹诺酮类药物对抗生素耐药质粒维持与转移的抑制作用
[Inhibition of the maintenance and transfer of antibiotic-resistance plasmids by quinolones].
作者信息
Uccelli V, Laporte J M, Michel-Briand Y
出版信息
C R Seances Soc Biol Fil. 1985;179(5):696-9.
The role of quinolones in the maintenance and transfer of antibiotic resistance plasmids was investigated. Curing effect of eleven quinolones, at subinhibitory concentrations, was studied on Escherichia coli strains harbouring ten plasmids belonging to different incompatibility groups. R386, R446b and S-a were the only plasmids eliminated by all the quinolones at a rate between 0.5 to 16%. The best culture medium was human urine. A total inhibition of transfer of RP4 plasmid between two Escherichia coli strains was obtained with nalixidic and oxolinic acids and flumequin. A partial inhibition was observed with other quinolones.
研究了喹诺酮类药物在抗生素耐药质粒维持和转移中的作用。在亚抑制浓度下，研究了11种喹诺酮类药物对携带10种属于不同不相容群质粒的大肠杆菌菌株的消除效果。R386、R446b和S-a是仅有的能被所有喹诺酮类药物以0.5%至16%的速率消除的质粒。最佳培养基是人尿。萘啶酸、恶喹酸和氟甲喹完全抑制了RP4质粒在两种大肠杆菌菌株之间的转移。其他喹诺酮类药物观察到部分抑制作用。
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