某些最近合成的4-喹诺酮化合物对质粒接合的抑制作用。
Inhibition of plasmid conjugation by some recently synthetized 4-quinolone compounds.
作者信息
Scazzocchio F, Selan L, Oliva B, Schippa S, Cellini L, Renzini G
机构信息
Microbiology Institute, Pharmacy Faculty, La Sapienza University, Rome, Italy.
出版信息
Chemioterapia. 1988 Oct;7(5):295-7.
Four fluoroquinolones (norfloxacin, ciprofloxacin, ofloxacin, and pefloxacin) were compared with nalidixic acid for their inhibitory effect on conjugal plasmid transfer. The inhibition was observed in mating experiments using various combinations of drugs at subinhibitory concentrations and 3 different plasmids in the E. coli k12 genetic background. Fluoroquinolones inhibited plasmid transfer to a greater extent than nalidixic acid. Ofloxacin and pefloxacin were consistently the most active agents, causing 90 to 100% inhibition of plasmid transfer in all mating systems studied.
比较了四种氟喹诺酮类药物（诺氟沙星、环丙沙星、氧氟沙星和培氟沙星）与萘啶酸对接合质粒转移的抑制作用。在大肠杆菌K12遗传背景下，使用亚抑制浓度的各种药物组合和3种不同质粒进行的交配实验中观察到了抑制作用。氟喹诺酮类药物比萘啶酸对质粒转移的抑制作用更大。氧氟沙星和培氟沙星始终是最有效的药物，在所研究的所有交配系统中，它们对质粒转移的抑制率达90%至100%。
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