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冰片与间充质干细胞对小鼠缺血性脑卒中的相加神经保护作用

Additive Neuroprotective Effect of Borneol with Mesenchymal Stem Cells on Ischemic Stroke in Mice.

作者信息

Zhang Xiao-Guang, Shan Chang, Zhu Jia-Zhen, Bao Xiao-Yi, Tong Qiang, Wu Xi-Fan, Tang Xiao-Chen, Xue Ting, Liu Jie, Zheng Guo-Qing, Wang Yan

机构信息

Department of Internal Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China.

出版信息

Front Physiol. 2018 Jan 17;8:1133. doi: 10.3389/fphys.2017.01133. eCollection 2017.

DOI:10.3389/fphys.2017.01133
PMID:29387017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5776113/
Abstract

Intravenous stem cell transplantation initiates neuroprotection related to the secretion of trophic factor. Borneol, a potential herbal neuroprotective agent, is a penetration enhancer. Here, we aimed to investigate whether they have additive neuroprotective effect on cerebral ischemia. Borneol was given to mice by gavage 3 days before middle cerebral artery occlusion (MCAO) induction until the day when the mice were sacrificed. Mesenchymal stem cells (MSCs) were intravenously injected at 24 h after MCAO induction. Neurological deficits, infarct volume, cell death, and neurogenesis were evaluated. Combined use of MSCs and borneol could more effectively reduce infarction volume and cell apoptosis, enhance neurogenesis, and improve the functional recovery than that of MSCs alone. The findings showed that combined use of borneol and stem cells provided additive neuroprotective effect on cerebral ischemia. However, the supposed effect of borneol on the improved MSC penetration still needs further direct evidence.

摘要

静脉内干细胞移植启动与营养因子分泌相关的神经保护作用。冰片是一种潜在的草药神经保护剂，是一种渗透增强剂。在此，我们旨在研究它们对脑缺血是否具有相加的神经保护作用。在诱导大脑中动脉闭塞（MCAO）前3天直至处死小鼠当天，通过灌胃给予小鼠冰片。在MCAO诱导后24小时静脉注射间充质干细胞（MSC）。评估神经功能缺损、梗死体积、细胞死亡和神经发生情况。与单独使用MSC相比，联合使用MSC和冰片能更有效地减少梗死体积和细胞凋亡，增强神经发生，并改善功能恢复。研究结果表明，冰片和干细胞联合使用对脑缺血具有相加的神经保护作用。然而，冰片对改善MSC渗透的假定作用仍需要进一步的直接证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/388f1b7a45d4/fphys-08-01133-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/3d3435b05437/fphys-08-01133-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/00331dbc7045/fphys-08-01133-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/e69a2c355220/fphys-08-01133-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/22478e7b23a9/fphys-08-01133-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/8e8a9e2457e6/fphys-08-01133-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/388f1b7a45d4/fphys-08-01133-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/3d3435b05437/fphys-08-01133-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/00331dbc7045/fphys-08-01133-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/e69a2c355220/fphys-08-01133-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/22478e7b23a9/fphys-08-01133-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/8e8a9e2457e6/fphys-08-01133-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d54b/5776113/388f1b7a45d4/fphys-08-01133-g0006.jpg

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