Institute of Reproductive and Child Health, Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Peking University, Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Metab Brain Dis. 2018 Jun;33(3):837-842. doi: 10.1007/s11011-017-0172-4. Epub 2018 Feb 1.
Congenital hydrocephalus (CH) was a major birth defect of the central nervous system besides neural tube defects (NTDs). Few studies have focused on both the prevalence and trend of isolated and complicated CH in China. Data were drawn from a population-based birth defects surveillance program in five rural counties in northern China from 2005 to 2015. All livebirths and pregnancy terminations at any gestational age affected with CH were recorded. The prevalence and trend of isolated and complicated CH were examined. During the 11-year period, a total of 176,223 births and 357 CH cases were recorded, resulting in a prevalence rate of 20.3 CH cases per 10,000 births. Of the CH cases, 146 were isolated CH, resulting in a prevalence rate of 8.3 per 10,000 births. The pre-perinatal prevalence (<28 gestational weeks) was higher than the perinatal prevalence for both isolated and total CH. The prevalence rates of total and isolated CH showed a similar downward trend during the 11-year period. This downward trend was statistically significant after 2009 (p < 0.05), when a massive folic acid supplementation program was introduced. Although it decreased over time, the prevalence of CH remains high in this population which has a high prevalence of neural tube defects.
先天性脑积水（CH）是除神经管缺陷（NTDs）以外的中枢神经系统的主要出生缺陷。很少有研究关注中国孤立性和复杂性 CH 的流行率和趋势。数据来自中国北方五个农村县的基于人群的出生缺陷监测计划，时间跨度为 2005 年至 2015 年。记录了所有受影响的活产儿和任何妊娠周龄终止妊娠的 CH。检查了孤立性和复杂性 CH 的流行率和趋势。在 11 年期间，共记录了 176,223 例活产儿和 357 例 CH 病例，CH 的患病率为每 10,000 例活产儿 20.3 例。在 CH 病例中，146 例为孤立性 CH，患病率为每 10,000 例活产儿 8.3 例。围产前（<28 孕周）患病率高于孤立性和总 CH 的围产患病率。总 CH 和孤立性 CH 的患病率在 11 年间呈相似的下降趋势。自 2009 年（p<0.05）大规模叶酸补充计划实施以来，这种下降趋势具有统计学意义。尽管患病率随时间降低，但在神经管缺陷高发的人群中，CH 的患病率仍然很高。
