Qian Lili, Zhang Yu, Cui Dawei, Lou Bin, Chen Yimin, Yu Ying, Liu Yonglin, Chen Yu
Department of Laboratory Medicine, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Department of Laboratory Medicine, Center of Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou, 310003, China.
BMC Infect Dis. 2017 Jun 5;17(1):393. doi: 10.1186/s12879-017-2498-2.
BACKGROUND: HPV infection is the major pathogenic factor underlying cervical cancer and precancerous lesions. The cervical HPV infection rates in gynaecological outpatients from Hangzhou, China, were studied in the period from January 2011 to December 2015. METHODS: Exfoliated cervical cells were harvested from gynaecological outpatients in Hangzhou from January 2011 to December 2015. Twenty-one HPV subtypes were detected using flow-through hybridization. The HPV infection rates in various disease groups were compared using the Chi-square test. The infection rates of different HPV subtypes in different calendar years and in different age groups were analysed using the linear-by-linear association test and gamma value.
A total of 43,804 patients were recruited, of whom 9752 (22.3%) were infected with HPV. The top five among the 21 HPV subtypes detected in terms of infection rates were HPV-16, -52, -58, -53 and -18. No significant differences (linear-by-linear association test) were found in the HPV infection rates when compared over the studied years (P > 0.05). However, the 15-24-year-old age group showed the highest HPV infection rate, and significant differences (linear-by-linear association test) were detected among the different age groups (P < 0.05). The HPV infection rates exhibited an upward trend in the 15-24-year-old and >24-34-year-old groups over the past five years. There were significant differences in the HPV infection rates among the disease groups (P < 0.05).
HPV-16, -52 and -58 were the major HPV infection subtypes in Hangzhou, China. The 15-24-year-old age group had a relatively high HPV infection rate with an upward trend over the past five years and thus represented a population susceptible to HPV infection.
背景：人乳头瘤病毒（HPV）感染是宫颈癌及癌前病变的主要致病因素。对2011年1月至2015年12月期间中国杭州妇科门诊患者的宫颈HPV感染率进行了研究。方法：收集2011年1月至2015年12月杭州妇科门诊患者的宫颈脱落细胞。采用流氏杂交法检测21种HPV亚型。使用卡方检验比较各疾病组的HPV感染率。采用线性趋势检验和伽马值分析不同历年及不同年龄组中不同HPV亚型的感染率。结果：共纳入43804例患者，其中9752例（22.3%）感染HPV。在所检测的21种HPV亚型中，感染率排名前五位的是HPV-16、-52、-58、-53和-18。在所研究的年份中，HPV感染率比较差异无统计学意义（线性趋势检验，P>0.05）。然而，15-24岁年龄组的HPV感染率最高，不同年龄组间差异有统计学意义（线性趋势检验，P<0.05）。在过去五年中，15-24岁组和>24-34岁组的HPV感染率呈上升趋势。疾病组间的HPV感染率差异有统计学意义（P<0.05）。结论：HPV-16、-52和-58是中国杭州主要的HPV感染亚型。15-24岁年龄组HPV感染率相对较高，且在过去五年呈上升趋势，是HPV感染的易感人群。
