Mir J, Franken D, Andrabi S W, Ashraf M, Rao K
Department of Andrology, Milann Hospital, Bangalore, India.
Department of Obstetrics and Gynaecology, University of the Free State, Bloemfontein, South Africa.
Andrologia. 2018 Feb 1. doi: 10.1111/and.12957.
The objective of the study was to determine whether weight loss in obese men improves their fertility with respect to DNA fragmentation index and morphology. Collected fertility parameters included DFI and morphology. Body mass index (BMI) was calculated for all patients with comparisons to their fertility parameters before and after weight loss using paired t test and chi-square tests. The mean BMI was significantly higher in group 1, before weight loss (33.18 kg/m ), than in group 2, after weight loss (30.43 kg/m ). Overall, 53.3% of men had DFI <20% while 43.8% had a DFI between 20% and 40%, and 2.9% of men had DFI >40%. The mean DFI of participants was higher before weight loss (20.2%) and had improved significantly after weight loss (17.5%) (p = <.001). The weight loss had significant positive correlation with percentage of DFI. There was a significant improvement in morphology after weight loss (p = <.05). In one of the largest cohorts of male fertility and obesity, DFI and morphology demonstrated significant relationship with adiposity, possibly contributing to subfertility in this population.
该研究的目的是确定肥胖男性体重减轻是否会在DNA碎片化指数和形态方面改善其生育能力。收集的生育参数包括DFI和形态。计算所有患者的体重指数（BMI），并使用配对t检验和卡方检验将其与体重减轻前后的生育参数进行比较。第1组在体重减轻前的平均BMI（33.18kg/m²）显著高于第2组在体重减轻后的平均BMI（30.43kg/m²）。总体而言，53.3%的男性DFI<20%，而43.8%的男性DFI在20%至40%之间，2.9%的男性DFI>40%。参与者的平均DFI在体重减轻前较高（20.2%），在体重减轻后显著改善（17.5%）（p<0.001）。体重减轻与DFI百分比呈显著正相关。体重减轻后形态有显著改善（p<0.05）。在最大的男性生育与肥胖队列之一中，DFI和形态与肥胖呈现显著关系，这可能导致该人群的生育力低下。
